E3 Flashcards

0
Q

Neostriatal Pathway

A

Movement

SNc —MFB–> caudate/putamen

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1
Q

Dopamine Pathways (2)

A

(1) Neostriatal

(2) Mesolimbic

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2
Q

Mesolimbic Pathway

A

Motivation & Reward

UTA –MFB–> NAc

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3
Q

Dopamine Receptors

A

D1, D2, D3, D4, D5

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4
Q

Dopamine

(1) Uptake
(2) Degradation

A

(1) DAT

(2) MAO & COMT

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5
Q

Loci of histamine synthesis

A

Somas of hypothalamus via widespread projections

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6
Q

Histamine Roles

A

(1) Arousal
(2) Attention
(3) Blood flow impact
(4) Imflammation

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7
Q

Tuberomammillary nucleus of hypothalamus

A

qq

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8
Q

Histamine Transporter

A

None identified

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9
Q

Histamine Degradation

A

(1) Histamine methyltransferase

(2) MAO

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10
Q

5-HT

A

5-Hydroxytryptophan

Role: Sleep, mood, depression, anxiety
Somas: Raphe nulei
Uptake: SERT
Degraded: MAO

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11
Q

Raphe nuclei

A

qq

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12
Q

Striatum

A

The input nucleus of the basal ganglia

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13
Q

SNr & GPi

A

Output nuclei

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14
Q

Striatal efferent (medium spiny) neuron

A

qq

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15
Q

Upper motor neurons

A

Cortex & Brainstem

16
Q

Lower motor neurons

A

Brainstem & Spinal cord

17
Q

BG & cerebellum

A

Influence upon upper motor n.s.