E3 Flashcards
Neostriatal Pathway
Movement
SNc —MFB–> caudate/putamen
Dopamine Pathways (2)
(1) Neostriatal
(2) Mesolimbic
Mesolimbic Pathway
Motivation & Reward
UTA –MFB–> NAc
Dopamine Receptors
D1, D2, D3, D4, D5
Dopamine
(1) Uptake
(2) Degradation
(1) DAT
(2) MAO & COMT
Loci of histamine synthesis
Somas of hypothalamus via widespread projections
Histamine Roles
(1) Arousal
(2) Attention
(3) Blood flow impact
(4) Imflammation
Tuberomammillary nucleus of hypothalamus
Histamine Transporter
None identified
Histamine Degradation
(1) Histamine methyltransferase
(2) MAO
5-HT
5-Hydroxytryptophan
Role: Sleep, mood, depression, anxiety
Somas: Raphe nulei
Uptake: SERT
Degraded: MAO
Raphe nuclei
Striatum
The input nucleus of the basal ganglia
SNr & GPi
Output nuclei
Striatal efferent (medium spiny) neuron