E2 reactions Flashcards
1
Q
Best carbon to work with
A
3
2
1
2
Q
Best nuc
A
strong
3
Q
Smaller nuc vs larger nuc
A
Smaller is able to get into crowded areas, while the larger needs more space
4
Q
Reaction
A
-All happens at the same time
1. Nucl grabs H
2. H bond created double bond with the C that Br is leaving from
3. Br leaves
5
Q
Sterochemistry
A
The nucleophile will be particular on what its taking from.
6
Q
Why does H need to be anti
A
There is room for the nuc to be able to come in
7
Q
What if it doesn’t look anti
A
Bonds can rotate making it anti
8
Q
E2 nuc
A
(CH3)3C-O
DBN
DBU
9
Q
Other leaving groups besides the regular 4
A
Tosylates Ts-O
Mesylate Ms-O
Triflate Tf-o
