E x a m 4 Flashcards
This drug is a melatonin receptor agonist with a very short half life of 2-5 hours.
no potential for abuse.
Interactions: Fluvoxamine inhibits metabolism
Ramelteon
This classification of medications works on GABA receptors and were the first sedative drugs with many adverse effects including:
fatal respiratory depression, high potential for drug abuse
induce hepatic drug metabolism
Barbiturates
This drug is a 5-HT serotonin receptor partial agonist. It is used for anxiety for short term use.
Buspirone
This classification of medications works on GABA receptors and have replaced barbiturates
Onset time in all cases is fast (15 to 60 minutes) with a medium-long duration (7 to 100 hours) for most useful in general anxiety disorder, alcohol withdrawal.
________ or _________ are useful in seizures and _________ is a very good drug choice for the elderly
Taper off drug slowly.
all end in -zolam and -zepam
Benzodiazepines
Diazepam
Lorazepam
This classification of sedatives/hypnotics was developed most recently.
Adverse effects include daytime drowsiness, sleep driving
It includes 3 drugs:
Benzodiazepine-like
zolpidem
Zaleplon
Eszopiclone
This drug is a GABA receptor competitive antagonist so it is able to reverse the sedative effects of benzodiazepines and some benzodiazepine-like drugs.
It does not reverse the respiratory depression
It can cause seizures in patients who have taken benzodiazepines for a long period of time
Flumazenil
G0 is another name for this phase of resting during the cell cycle:
the quiescent phase
This is the result of abnormal cells that persistently divide and grow without control.
Cancer
Anticancer Drugs
This is the largest class of anticancer drugs. Act directly on cells to cause cell death
Cytotoxic Drugs
Anticancer Drugs
This broad class of drugs includes the antiestrogens, for breast cancer, and the antiandrogens, for prostate cancer.
Hormonal Drugs
This is the ratio of proliferating cells to resting cells.
Growth Fraction
This is an abnormal tissue growth that forms a mass.
tumor
Extravasation of these types of drugs can cause severe local injury.
Vesicant drugs
Normal bone marrow, hair follicles, GI epithelium and testes are all these types of cells, making them more susceptible to effects of cytotoxic drugs
High Growth Fraction cells
This is the effect of cytotoxic drugs on hair follicles
Alopecia
This word indicates a tumor does not invade nearby tissue and does not spread to other parts of the body
Benign
Cells in this phase are undergoing cell division, or mitosis.
The Proliferation Phase
These are the effects of cytotoxic drugs on the GI tract
Stomatitis, diarrhea, nausea and vomiting
This word indicates a tumor that invades nearby tissue or spreads throughout the body.
malignant