Dyspnea Flashcards
Hodgkin lymphoma is characterized by […] on biopsy
Reed Sternburg cells
Hodgkin lymphoma has a strong association with […]
EBV
localized single group of nodules with contiguous spread is characteristic of […] lymphoma
Hodgkin
(vs. Non-Hodgkin: multiple nodes involved, non-contiguous)
what chemo drug causes cardiotoxicity?
doxorubicin
what chemo drug causes pulmonary fibrosis?
bleomycin
what chemo drug causes peripheral neuropathy?
vincristine
MOA of vincristine
binds B-tubulin to inhibit microtubule polymerization
prevents formation of mitotic spindle
administer […] for acute obstructive, pulmonary events,like asthma exacerbation.
albuterol
what would you expect to see on CXR in empyhsema?
barrel chest
flattened diaphragm
increased lung field lucency
increased AP diameter (best seen on lateral)
[central or pan acinar]
Characterized by the destruction of the respiratory bronchiole; spares distal alveoli
Usually affects the upper lobes
central
[central or pan acinar]
associated with tobacco
central
[central or pan acinar]
Characterized by the destruction of the entire acinus
Usually affects the lower lobes
pan
[central or pan acinar]
associated with a1-antitrypsin deficiency
pan
Identify all five lobes on a CT scan showing emphysema
(note: this example is panacinar)
(this image does not have emphysema, but just a way to help visualize where the lobes are on CT)
Recognize a vignette of PTHrP induced hypercalcemia and get a chest […]
Xray
Witt: “this question was pulled from the main question bank because it has mammograpy as an option. Do not select mammography! On this PTHrP question, although you would do this in the real world”
MOA of tamoxifen
ER antagonist at the breast
ER agonist at uterus and bone
describe the pathophysiology of LEMS
autoantibodies directed against presynaptic voltage-gated calcium channels → ↓ Ca2+ influx → ↓ presynaptic vesicle fusion → impaired acetylcholine release in the NMJ
patients with […] are usually euvolemic, normotensive, and have no edema
SIADH
what type of cancer is associated with both SIADH and LEMS?
SCLC
Reed-Sternburg cells will stain CD[..] and CD[…] positive
15
30
Reed-Sternberg cells secrete […], which increase the expression of 1α-hydroxylase in malignant lymphocytes
INF-y
[…] improve survival in patients with chronic compensated heart failure by decreasing myocardial oxygen demand
beta blockers
PAS-positive, spherical inclusion bodies in periportal hepatocytes on liver biopsy
a1-antitrypsin deficiency
accumulation of AAT in hepatocellular endoplasmic reticulum causes [2]
hepatitis
liver cirrhosis
