Dyspnea

Question 1

Hodgkin lymphoma is characterized by […] on biopsy

Answer 1

Reed Sternburg cells

Question 2

Hodgkin lymphoma has a strong association with […]

Answer 2

EBV

Question 3

localized single group of nodules with contiguous spread is characteristic of […] lymphoma

Answer 3

Hodgkin

(vs. Non-Hodgkin: multiple nodes involved, non-contiguous)

Question 4

what chemo drug causes cardiotoxicity?

Answer 4

doxorubicin

Question 5

what chemo drug causes pulmonary fibrosis?

Answer 5

bleomycin

Question 6

what chemo drug causes peripheral neuropathy?

Answer 6

vincristine

Question 7

MOA of vincristine

Answer 7

binds B-tubulin to inhibit microtubule polymerization

prevents formation of mitotic spindle

Question 8

administer […] for acute obstructive, pulmonary events,like asthma exacerbation.

Answer 8

albuterol

Question 9

what would you expect to see on CXR in empyhsema?

Answer 9

barrel chest
flattened diaphragm
increased lung field lucency

increased AP diameter (best seen on lateral)

Question 10

[central or pan acinar]
Characterized by the destruction of the respiratory bronchiole; spares distal alveoli

Usually affects the upper lobes

Answer 10

central

Question 11

[central or pan acinar]
associated with tobacco

Answer 11

central

Question 12

[central or pan acinar]
Characterized by the destruction of the entire acinus
Usually affects the lower lobes

Answer 12

pan

Question 13

[central or pan acinar]
associated with a1-antitrypsin deficiency

Answer 13

pan

Question 14

Identify all five lobes on a CT scan showing emphysema

(note: this example is panacinar)

Answer 14

(this image does not have emphysema, but just a way to help visualize where the lobes are on CT)

Question 15

Recognize a vignette of PTHrP induced hypercalcemia and get a chest […]

Answer 15

Xray

Witt: “this question was pulled from the main question bank because it has mammograpy as an option. Do not select mammography! On this PTHrP question, although you would do this in the real world”

Question 16

MOA of tamoxifen

Answer 16

ER antagonist at the breast

ER agonist at uterus and bone

Question 17

describe the pathophysiology of LEMS

Answer 17

autoantibodies directed against presynaptic voltage-gated calcium channels → ↓ Ca2+ influx → ↓ presynaptic vesicle fusion → impaired acetylcholine release in the NMJ

Question 18

patients with […] are usually euvolemic, normotensive, and have no edema

Answer 18

SIADH

Question 19

what type of cancer is associated with both SIADH and LEMS?

Answer 19

SCLC

Question 20

Reed-Sternburg cells will stain CD[..] and CD[…] positive

Answer 20

15
30

Question 21

Reed-Sternberg cells secrete […], which increase the expression of 1α-hydroxylase in malignant lymphocytes

Answer 21

INF-y

Question 22

[…] improve survival in patients with chronic compensated heart failure by decreasing myocardial oxygen demand

Answer 22

beta blockers

Question 23

PAS-positive, spherical inclusion bodies in periportal hepatocytes on liver biopsy

Answer 23

a1-antitrypsin deficiency

Question 24

accumulation of AAT in hepatocellular endoplasmic reticulum causes [2]

Answer 24

hepatitis
liver cirrhosis