Dyspepsia Flashcards
1
Q
What is dyspepsia?
A
Predominant epigastric pain for at least 1 month
2
Q
Difference between organic and functional dyspepsia
A
- Organic = peptic ulcer disease, GERD, cancer
- Functional = non-ulcer
3
Q
Difference between PUD and GERD
A
- Peptic ulcer disease sx = episodic epigastric pain and heartburn
- GERD -> considered a chronic disease or chronically relapsing disorder; sx:
- Classical = regurgitation, heartburn, dysphagia, odynophagia (pain on swallowing)
- Atypical = coughing, wheezing, globus sensation, chest pain
4
Q
Potential causes of PUD and GERD
A
- Peptic ulcer disease -> H. pylori, NSAIDs, smoking, EtOH, caffeine
- GERD -> pregnancy, obesity, increased age, histus hernia
5
Q
What is considered PUD recurrence
A
- Failure of 8-week therapy in duodenal ulcer
- Failure of 12-week therapy in gastric ulcer
- *Always look for a reason (non-adherence, H. pylori, NSAIDs)
6
Q
Functional dyspepsia tx
A
- Functional dyspepsia: dyspepsia of at least 3 months w/ no clearly identifiable pathology
1. Test and treat for H pylori
2. Pt is H pylori negative -> endoscopy, PPI, prokinetics, CBT and other psychological approaches
3. If pt tries PPI and has no sx relief -> consider TCA (amitriptyline, imipramine) over prokinetics - 4 weeks is an adequate trial period
7
Q
Use of antacids for dyspepsia
A
- Peptic ulcer disease and GERD -> used for sx relief
- Take at 1 and 3 hours post-meal and at HS
- Can be used PRN for GERD
- AE = constipation/diarrhea, drug interactions
- *Important -> don’t use sodium bicarb products in CHF/cirrhosis px and don’t use magnesium products chronically in dialysis px (use aluminum or calcium instead)
- Functional dyspepsia -> limited to no benefit
8
Q
Use of H2 receptor blockers for dyspepsia
A
- All agents the same at appropriate dosage
- All can be given 1 or 2x/day
- GERD -> can be up to 2x the PUD dose (ex: ranitidine 300 mg BID) but rarely done b/c PPIs cost around the same
- AE = very low; drug interactions w/ cimetidine, so recommend ranitidine
9
Q
Use of PPIs for dyspepsia
A
- Gold standard for PUD and GERD
- Functional dyspepsia -> only small benefit; more beneficial for ulcer & reflux-like sx; limit to once daily
- Effects last 3 days
- Increasing omeprazole dose from 20 mg to 40 mg only decreases acid by further 6%
- AE = nausea, headache, dizziness, diarrhea, sweating
- Take 30 mins before morning meal or evening meal if primarily nocturnal sx
- *Don’t continue long-term unless attempt to stop/reduce tx at least once/year except if Barrett’s or GI bleed
10
Q
Drug interactions w/ PPIs
A
- Any drugs w/ low pH dependent absorption
- May increase MTX, digoxin, and tacrolimus levels
- Omeprazole and esomeprazole may decrease clopidogrel’s conversion to active drug; may consider switching to pantoprazole
11
Q
Red flags for dyspepsia
A
- Alarm features = VBAD (warrants prompt endoscopy)
- Vomiting > 7 days
- Bleeding
- Abdominal mass or unexplained weight loss (ex: 10% body weight)
- Dysphagia
- Others = jaundice, family hx of gastric cancer, prior ulcer
- Refractory GERD
12
Q
Case specific assessment questions for dyspepsia
A
- Do you regularly use NSAIDs?
- Is the predominant sx heartburn and/or regurgitation? (if yes, indicates GERD)
- Have you been tested for H. pylori?
13
Q
Non-pharms for dyspepsia (general)
A
- Peptic ulcer disease -> avoid large meals right before bed (increases HS acid production); avoid precipitants (NSAIDs, ASA, smoking, EtOH > 20% proof, excess caffeine)
- GERD and functional dyspepsia -> smaller, more frequent meals; avoid precipitants (certain foods, smoking, alcohol, caffeine); stress reduction; smoking cessation, exercise and weight loss
14
Q
General monitoring for dyspepsia
A
- For FD px, 4 weeks is plenty of time to determine if a drug is working or not
- Pt monitor symptoms daily
15
Q
General follow up for dyspepsia
A
- Pharmacist follow up in 1 week to see if sx improving
- Reassess GERD therapy in 4 weeks -> if sx improve, stop therapy; if sx don’t improve w/ PPI, increase to BID for 4-8 weeks then reassess
16
Q
Describe monitoring for PUD
A
- Monitor for sx improvement and side effects from the drug daily/weekly
- Common SE of PPI = N, headache, dizziness, diarrhea, constipation