Dyslipidemia Flashcards
Statins MOA
Inhibit HMG-CoA reductase
-Rate-limiting step in cholesterol biosynthesis
Effects of statins on lipid profile
Decrease LDL by 25-62%
Moderate reduction in TG
Minor increase in HDL
Pleiotropic effects of statins
Reduce lipoprotein oxidation
Enhance endothelial synthesis of nitric oxide
Inhibit thrombosis
First-line therapy
-Reduce ASCVD, mortality
-Effect seen across age, genders, disease states
Most common adverse effects of statins
Constipation Abd pain Diarrhea Dyspepsia Nausea
Other adverse effects of statins
Elevation in LFTs Myopathy including rhabdomyolysis -Small body frame -Multisystem disease -Perioperative periods -Taking interacting medications/substances -Increased blood glucose/ HbA1c -Cognitive impairment -Pregnancy category X
Options for statin intolerance
Change to another statin
-Preferably pravastatin
Dose reduction
Alternate day dosing
-For example, give 40 mg every other day instead of 20 mg q day
-Similar LDL lowering seen for atorvastatin, fluvastatin, and rosuvastatin
-No clinical outcomes data
-No daily doses >40 mg daily have been tested