Dynamic combinatorial chemistry

Question 1

Dynamic combinatorial chemistry

Answer 1

A method to the generation of new molecules formed by the reversible reaction of simple building blocks under thermodynamic control

Question 2

Dynamic combinatorial library

Answer 2

The library of reversibly interconverting building blocks
All constituents are in equilibrium and their distribution is determined by their thermodynamic stability within the library

Question 3

Reversible reactions in DCC

Answer 3

Scrambling of esters/thioesters
Disulfide bond scrambling
Imine exchange
Hydrazone exchange
H-bond scrambling

Question 4

How can a dynamic combinatorial library be analysed?

Answer 4

HPLC

Question 5

Acetylcholine structure

Answer 5

Draw

Question 6

External templating

Answer 6

Control of library distribution/selection through addition of a guest or host molecule

Question 7

Self-templating

Answer 7

Control of library distribution/selection through intra- or intermolecular interactions

Question 8

Dynamer

Answer 8

The polymer backbone can be reformed/repaired after manufacturing (“dynamic”)