Dupuytren Contracture (From Required Medscape Readings)

Question 1

Dupuytren disease is ____________________.

Answer 1

a fibrosing disorder that results in slowly progressive thickening and shorting of the palmar fascia and leads to debilitating digital contractures, particularly of the MCP

Question 2

Dupuytren’s typically starts out as ________________.

Answer 2

a nodule of myofibroblasts and then progresses to a cord of collagen

Question 3

Normal longitudinal components of the superficial palmar aponeurosis are referred to as ________; diseased tissue is referred to as ____________.

Answer 3

bands; cords

Question 4

What causes Dupuytren’s?

Answer 4

Proliferation of fibroblasts that leads to deposition of collagen

Question 5

What things can look like Dupuytren’s (and should be in your differential)?

Answer 5

• Ganglion cyst (which will be movable)
• Stenosing tenosynovitis (which will usually have a history of overuse)

Question 6

How can Dupuytren’s be treated?

Answer 6

• Observation
• PT
• Corticosteroid
• Surgical decompression
• Collagenase injections