DTP's and CPG's Flashcards
What are the indications for Aspirin?
- Suspected ACS
- Acute cardiogenic pulmonary oedema (cardiogenic APO)
What are the contraindications for Aspirin?
- Allergy / adverse drug reaction to aspirin or any NSAID
- Chest pain associated with psychostimulant overdose
- Bleeding or clotting disorders
- Current GI bleeding OR peptic ulcers
- less than 18 years
What are the precautions for Aspirin?
- Possible AAA or any other condition that may require surgery
- Pregnancy
- History of GI bleeding or peptic ulcers
- Concurrent anticoagulant therapy eg warfarin
What can be the side effects of Aspirin?
- Epigastric pain / discomfort
- Nausea / vomiting
- Gastritis
- GI bleeding
- NSAID induced bronchospasm
What is the adult dosage for Aspirin?
300mg - chewed, followed by small sip of water
What is the max daily dosage of Aspirin?
450 mg
What drug class is Aspirin?
Antiplatelet
Aspirin Pharmacology
Aspirin inhibits platelet aggregation by irreversibly inhibiting cyclo-oxygenase, reducing the synthesis of thromboxane A2 (an inducer of platelet aggregation) for the life of the platelet. This actions forms the basis of preventing platelets from aggregating to exposed collagen fibres at the site of vascular injury
What drug class is Droperidol?
Antipsychotic
What are the indications for Droperidol?
Acute behavioural disturbances (with a SAT Score >2)
What are the contraindications for Droperidol?
Absolute:
- Allergy / adverse drug reaction
- Parkinson’s disease
- Known Lewy body dementia
- Previous dystonic reaction to droperidol
- < 8 years
Relative: (requires consult line)
- suspected sepsis
What are the side effects of Droperidol?
Vasodilation / hypotension
Extrapyramidal effects eg dystonic reactions (rare)
What is the presentation of Droperidol?
Vial 10mg/2mL
What is the IM & IV Adult dosage of Droperidol for a patient aged 13-15 years? Does it require a consult?
0.1 - 0.2 mg.kg
Single max dose 10mg
May be repeated once at 15 min
Total max dose 20mg
It requires a consult and approval
What is the IM & IV Adult dosage of Droperidol for a patient over 65 years? Does it require a consult?
5mg
May be repeated once at 15min
Total max dose 10mg
Consult and approval is required
What is the IM & IV Adult Droperidol dosage for a patient aged 16 to < 65 years? Does it require a consult?
10mg
May be repeated once at 15 min
Totak max dose 20mg
No consult required
What are the precautions for Droperidol?
Hypoperfused state
Concurrent use of CNS depressants
What drug class is Ondansetron?
Anti-emetic – 5-HT3 antagonist
What is the pharmacology of Ondansetron, how does it work?
Ondansetron is a serotonin 5-HT3 receptor antagonist. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.
What are the indications of Ondansetron?
Significant nausea / vomiting
What are the contraindications of Ondansetron?
Absolute:
- allergy / adverse drug reaction
- Congenital long QT syndrome
- Current apomorphine therapy (used in severe Parkinson’s)
- < 2 years
Relative:
- First trimester pregnancy (may only be administered for extreme and uncontrolled hyperemesis)
What can the adverse effects of Ondansetron be? Common and Rare
Common
- headache
- constipation
Rare
- hypersensitivity reactions (including anaphylaxis)
- ECG changes
What is Ondansetron’s Presentation?
Ampoule - 4mg/2mL
Oral tablet - 4mg
What is the adult dosage of Ondansetron PO or IM?
4-8mg
Total max dose 8mg
Must not be given within 8 hours of previous administration
What is the Adult dosage of Ondansetron IV?
4-8mg
Slow push over 2-3 minutes
Total max 8mg
Must not be given within 8 hours of previous administration
What is the PO paediatric dosage of Ondansetron for a patient over 5 years?
4mg single dose
What is the PO paediatric dosage of Ondansetron for a patient aged 2-4 years?
2mg single dose
What is the IM paediatric dosage of Ondansetron for a patients older than 2 years?
100 microg / kg (rounded to nearest 5kg)
Single dose - must not exceed 4mg
15-20kg - 2mg - 1ml
20-25kg - 2.5mg - 1.25ml
25-30kg - 3mg - 1.5ml
30-35kg - 3.5mg - 1.75ml
>35kg - 4mg - 2ml
What is the paediatric dosage of IV Ondansetron for patients over 2 years?
100 microg/kg
Slow push over 2-3min
Single dose, not to exceed 4mg
Can an IV cannula be inserted for the sole purpose of ondansetron administration?
NO
A patient is having an active seizure, what is the treatment?
- Protect the patient from injury
- Reversible causes
- Oxygen
- IPPV
- Midazolam (5mg IM / 200microg/kg for Paediatric)
- Levetiracetam
A patient has just stopped actively seizing, what is the treatment?
- reversible causes
- oxygen
- posturing
- PNES
What is a Focal Seizure?
Seizure activity that does not impair awareness or responsiveness
What is a Generalised seizure? What are the 5 types?
A generalised seizure is where abnormal neuronal activity rapidly engages both hemispheres of the cerebral cortex.
- Absence: brief ALOC with no post-ictal
- Atonic: Sudden loss of muscle tone resulting in a fall
- Tonic: sudden increased muscle tone that most often occurs in clusters during sleep
- Myoclonic: brief sudden jerking action of a muscle
- Tonic Clonic: abrupt LOC that is concurrent with involuntary muscular contractions (tonic phase) followed by symmetrical jerking movements (clonic phase)
What is status epilepticus?
Seizure activity lasting 5+ min or recurrent seizure activity where the patient does not recover to a GCS of 15 prior to another seizure
What are seizure triggers in epilepsy?
- Lack of sleep & stress
- sudden stopping or changing medications
- fever / infection
- diarrhoea, vomiting & dehydration
- alcohol / drug use
- menstruation
- photosensitivity
- extreme temperatures, mainly heat
- electrolyte disturbances
What are the indications for Morphine?
- Significant pain
- Sedation
- Autonomic dysreflexia (systolic BP >160)
Morphine is preferred narcotic except for: allergy/adverse reaction, haemodynamic instability, suspected kidney failure, NAS narcotic administration is preferred treatment, suspected ACS
What are the contraindications for Morphine?
- Allergy/adverse drug reaction
- Kidney disease (renal failure)
What are the precautions for Morphine?
- Hypotension
- Respiratory tract burns
- Respiratory depression/failure
- Known addiction to narcotics
- Concurrent MAOI therapy
- Cardiac chest pain
What are the side effects of Morphine?
- Bradycardia
- Drowsiness
- Hypotension
- Nausea/vomiting
- Pinpoint pupils
- Respiratory depression
What is the adult IM dosage of Morphine?
> 70 yrs / cachectic or frail
2.5-5 mg
Repeated up to 5 mg every 10 min
Max dose 10 mg
<70 yrs
2.5-10 mg
Repeated at up to 5 mg every 10 min
Max dose 20 mg
What is the adult IV dosage of Morphine?
> 70 yrs / cachectic or frail
2.5-5 mg
Repeated up to 2.5 mg every 10 min
Max dose 10 mg
<70 yrs
2.5-5 mg
Repeated at up to 5 mg every 10 min
Max dose 20 mg
What is the paediatric IM dosage for Morphine?
> 1 year
100-200 microg / kg
Single max dose 5mg. total max dose 200 microg/kg
What is the paediatric IV dosage for Morphine?
> 1 year
100 microg / kg
Single max dose 2.5mg
Repeated at 50 microg/kg at 5 min intervals
Total max dose 200 microg/kg
What is the presentation of Morphine?
Ampoule 10mg/1ml
What is the pharmacology of Morphine? What effects does it have on the body?
A narcotic analgesic that acts on the CNS by building with opioid receptors, altering processes affecting pain perception and emotional response to pain. It also combines to cause respiratory depression, vasodilation, decreasing in the gag reflex and slows AV node conduction