DSM-5 criteria Flashcards
Criteria for depression
Mood - depressed
Sleep - increased/decreased
Interest/pleasure - diminished
Guilt or feeling of worthlessness
Energy - decreased
Concentration - decreased
Appetite - increased/decreased
Pyschomotor agitation or retardation
Suicidal Ideation
M SIG E CAPS
Why is it important to rule out Bipolar before starting antidepressants
could induce mania or rapid cyclying
Drugs that can worsen depression
Atomoxetine
Indomethacin
Efavirenz
Rilpivirine
Beta blockers
Hormonal Contraceptives
Anabolic steroids
Benzodiazepines
systemic steroids
Interferons
Varenicline
Ethanol
How long should antidepressants be given to work
4-8 wks
Medication that increase serotonin syndrome
SSRI
SNRI
TCAs
Fentanyl
methadone
lithium
tramadol
buspirone
triptans
St Johns wort
Serotonin syndrome symptoms
severe nausea
dizziness
HA
diarrhea
agitation
tachycardia
hallucinations
What should be done to when stopping antidepressants
taper over several weeks
What SSRI self tapers
Fluoxetine because of long half life
What drugs are used to augment with antidepressants
Buspirone
Low dose atypical antipsychotic
abilify
olanzapine + fluoxetine
Seroquel XR
brexpiprazole
Esketamine
Lithium
What antidepressants can be used initially for pregancy
SSRI
Postpartum drugs that are preferred to be used
SSRI
TCAs
What SSRI shoudl not be used in pregancy
paroxetine
What TCA should not be used for postpartum depression
doxepin
SSRI MOA
increase 5-HT
Celexa
citalopram
lexapro
escitalopram
prozac
fluoxetine
Sarafem
fluoxetine
Paroxetine
paxil
sertraline
zoloft
max dosing celexa
40mg/ day
celexa dosing
20-40mg
Lexapro max dosing
20mg/day
celexa max dosing > 60yrs
20mg/day
lexapro max dosing > 60yrs old
10mg/day
Prozac max dosing
80mg/day
Prozac dosing
10-60mg/day
Symbyax
fluoxetine + olanzapine
Sarafem indication
prementral dysphoric disorder
symbyax indication
treatment resistant depression
brisdelle indication
vasomotor symptoms
brisdelle
paroextine
sarafem dosing
20mg/day
Paxil IR dosing
10-60mg/day
Paxil CR dosing
12.5-62.5mg/day
sertraline
zoloft
zoloft dosing
50-200mg/day
contraindication with SSRIs
MAOI Inhibitors
linexolid
IV Methyline blue
pimozide
What disorder should not be used with brisdelle
pregnancy
Warning for SSRIs
QT prolongation
hyponatremia
fall risk
bleeding
Side Effects of SSRIs
decreased libido
ejaculation difficulties
erectile dysfunction
somnolence
insomnia
nausea
dry mouth
diaphoresis
weakness
tremor
diszziness
HA
Most activating SSRI
fluoxetine
Most sedating
paroxetine
What SSRI is preferred in pt with cardiac risk
sertraline
What is the washout period with SSRIs and MAOIs
two week
5 weeks with fluoxetine b/c of half life
QT prolongation is see most consistantly with which SSRIs
lexapro and celexa
fluoxetine and paroxetine inhibit what liver enzyme
CYP2D6
what is the preferred SNRI with tamoxifen
Venlafaxine
Vilazodone
Viibryd
Viibryd MOA
SSRI and -HT1A partial Agonist
Vortioxetine
trintellix
Trintellx MOA
SSRI and 5HT3 antagonist and 5HT1A agonist
Viibryd should be taken with food T/F
True