DSM-5 criteria Flashcards

1
Q

Criteria for depression

A

Mood - depressed
Sleep - increased/decreased
Interest/pleasure - diminished
Guilt or feeling of worthlessness
Energy - decreased
Concentration - decreased
Appetite - increased/decreased
Pyschomotor agitation or retardation
Suicidal Ideation
M SIG E CAPS

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2
Q

Why is it important to rule out Bipolar before starting antidepressants

A

could induce mania or rapid cyclying

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3
Q

Drugs that can worsen depression

A

Atomoxetine
Indomethacin
Efavirenz
Rilpivirine
Beta blockers
Hormonal Contraceptives
Anabolic steroids
Benzodiazepines
systemic steroids
Interferons
Varenicline
Ethanol

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4
Q

How long should antidepressants be given to work

A

4-8 wks

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5
Q

Medication that increase serotonin syndrome

A

SSRI
SNRI
TCAs
Fentanyl
methadone
lithium
tramadol
buspirone
triptans
St Johns wort

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6
Q

Serotonin syndrome symptoms

A

severe nausea
dizziness
HA
diarrhea
agitation
tachycardia
hallucinations

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7
Q

What should be done to when stopping antidepressants

A

taper over several weeks

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8
Q

What SSRI self tapers

A

Fluoxetine because of long half life

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9
Q

What drugs are used to augment with antidepressants

A

Buspirone
Low dose atypical antipsychotic
abilify
olanzapine + fluoxetine
Seroquel XR
brexpiprazole
Esketamine
Lithium

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10
Q

What antidepressants can be used initially for pregancy

A

SSRI

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11
Q

Postpartum drugs that are preferred to be used

A

SSRI
TCAs

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12
Q

What SSRI shoudl not be used in pregancy

A

paroxetine

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13
Q

What TCA should not be used for postpartum depression

A

doxepin

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14
Q

SSRI MOA

A

increase 5-HT

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15
Q

Celexa

A

citalopram

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16
Q

lexapro

A

escitalopram

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17
Q

prozac

A

fluoxetine

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18
Q

Sarafem

A

fluoxetine

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19
Q

Paroxetine

A

paxil

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20
Q

sertraline

A

zoloft

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21
Q

max dosing celexa

A

40mg/ day

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22
Q

celexa dosing

23
Q

Lexapro max dosing

24
Q

celexa max dosing > 60yrs

25
Q

lexapro max dosing > 60yrs old

26
Q

Prozac max dosing

27
Q

Prozac dosing

A

10-60mg/day

28
Q

Symbyax

A

fluoxetine + olanzapine

29
Q

Sarafem indication

A

prementral dysphoric disorder

30
Q

symbyax indication

A

treatment resistant depression

31
Q

brisdelle indication

A

vasomotor symptoms

32
Q

brisdelle

A

paroextine

33
Q

sarafem dosing

34
Q

Paxil IR dosing

A

10-60mg/day

35
Q

Paxil CR dosing

A

12.5-62.5mg/day

36
Q

sertraline

37
Q

zoloft dosing

A

50-200mg/day

38
Q

contraindication with SSRIs

A

MAOI Inhibitors
linexolid
IV Methyline blue
pimozide

39
Q

What disorder should not be used with brisdelle

40
Q

Warning for SSRIs

A

QT prolongation
hyponatremia
fall risk
bleeding

41
Q

Side Effects of SSRIs

A

decreased libido
ejaculation difficulties
erectile dysfunction
somnolence
insomnia
nausea
dry mouth
diaphoresis
weakness
tremor
diszziness
HA

42
Q

Most activating SSRI

A

fluoxetine

43
Q

Most sedating

A

paroxetine

44
Q

What SSRI is preferred in pt with cardiac risk

A

sertraline

45
Q

What is the washout period with SSRIs and MAOIs

A

two week
5 weeks with fluoxetine b/c of half life

46
Q

QT prolongation is see most consistantly with which SSRIs

A

lexapro and celexa

47
Q

fluoxetine and paroxetine inhibit what liver enzyme

48
Q

what is the preferred SNRI with tamoxifen

A

Venlafaxine

49
Q

Vilazodone

50
Q

Viibryd MOA

A

SSRI and -HT1A partial Agonist

51
Q

Vortioxetine

A

trintellix

52
Q

Trintellx MOA

A

SSRI and 5HT3 antagonist and 5HT1A agonist

53
Q

Viibryd should be taken with food T/F