drying

Question 1

what are the two types of manufacturing?

Answer 1

primary and secondary

Question 2

what is primary manufacturing for?

Answer 2

synthesis of actives

Question 3

what is secondary manufacturing for?

Answer 3

production of dosage form

Question 4

what happens in primary manufacturing?

Answer 4

water is capable of degrading many drugs
hydrolytic degradation is highly discouraged

Question 5

what happens in secondary manufacturing?

Answer 5

wet granulation is used to prepare formulation prior to tablet compaction
stability, flow and compaction properties are influenced by residual water content.

Question 6

what are the methods of determining moisture content?

Answer 6

karl fischer potentiometric titration
dynamic vapour sorption
thermogravimetric analysis

Question 7

what is karl fischer titration

Answer 7

measure the amount (moles) of water by the electrical conductivity of a redox titration

Question 8

what is dynamic vapour sorption

Answer 8

measure the weight change as a function of both temperature and humidity.

Question 9

what is thermogravimetric analysis?

Answer 9

measure the weight change as a function of temperature

Question 10

what are the types of drying method

Question 11

what is total moisture content

Answer 11

total water content of a wet solid
not all of this water content can be easily removed
easily removable water content is referred to as free moisture content or unbound water