Drugy drug drugs Flashcards
Loperamide (Imodium) is used for?
mild to moderate diarrhea without obstruction, IBD, IBS
IBS–diarrhea dominant
Loperamide (Imodium) is what class?
Anti-diarrheal
Is Loperamide (Imodium) an opioid?
Yes
Is Kaolin-Pectin an opioid?
No
What class of drugs does Kaolin-Pectin belong to?
Anti-diarrheal
What is dietary fiber used for?
Anti-diarrheal and laxative
When do we use Octreotide (Sandostatin)?
GI bleed–diarrhea secondary to bowel dysmotility
Does high dose or low dose of Octerotide increase motility?
Low dose
When do we use Bismuth Subsalicylate (BSS)?
mild, nonspecific diarrhea, part of quadruple treatment for H. pylori
How do we treat severe IBD?
TNF antagonists, Natalizumab, Cyclosporine
Moderate IBD treatment?
Oral corticosteroids, methotrexate
Mild IBD treatment?
5-ASA, budesonide
Where does Sulfasalazine work in the GI tract? Osalazine? Mesalamine pH sensitive release?
Sulfasalazine: colon
Osalazine: colon
Mesalamine pH sensitive release: ileum
What is Azathioprine indicated for?
steroid sparing for steroid dependent Crohn’s disease, ulcerative colitis
What kind of drug is Infliximab (Remicade) and what is it used for?
Anti-TNF alfa-inflammatory agent
Indication: acute and maintenance treatment for moderate to severe Crohn’s disease and UC
When do we use Natalizumab?
It is for a subset of patients with moderate to severe Crohn’s disease who have failed other therapies
What is our one and only gallstone medication?
Ursodiol
What is Senakot (Senna) used for?
Constipation
What do we use Lubiprostone (Amitiza) for?
Chronic idiopathic constipation
IBS-Constipation in women
What do we use Linaclotide (Linzess) for?
IBS-Constipation or chronic idiopathic constipation
How does Lubiprostone work?
activates calcium channels to increase bowel fluid secretion and motility
How does Linaclotide work?
agonizes cGMP on luminal surface of bowel epithelium
What do we use MiraLax for?
Bowel prep
