Drugs used to promote attn and wakefulness

Question 1

5 examples of trad CNS stimulants (4)

Answer 1

1. Methylphenidate (Ritalin), extended release (Concerta)
2. Dexmethylphenidate (Focalin)
3. Dextroamphetamine (Dexedrine)
4. Amphetamine/dextroamphetamine (Adderall)

Question 2

S/Es of trad CNS stimulants (5)

Answer 2

1. anxiety
2. insomnia
3. anorexia
4. tachycardia
5. HTN!!

Question 3

Contraindications for CNS stimulants? (2)

Answer 3

• Coadministration w/ MAOIs

- Narrow angle glaucoma

Question 4

Mechanism of action of trad CNS stimulants?

Answer 4

• stimulation of alpha and beta adrenergic receptors –> triggers release of dopamine and NE from presynaptic terminals

Question 5

What must you watch for when using methylphenidate? (3)

Answer 5

• leukopenia
• anemia
• increased LFTs

Question 6

Mechanism of action of Atomoxetine?

Answer 6

• presynaptic NE transporter inhibitor

Question 7

Serious adverse effects of Atomoxetine? (2)

Answer 7

• suicidal ideation (black box warning)

- severe liver injury (rare)

Question 8

What is primarily used in tx of narcolepsy?

Answer 8

Modafinil

Question 9

Side effects of modafinil (5)

Answer 9

1. headache
2. Nausea
3. Rhinitis
4. Anxiety
5. Insomnia