Drugs used in Thyroid Disorders Flashcards
Which hormone is released by the hypothalamus and controls thyroid hormone secretion?
Thyrotropin-Releasing Hormone (TRH).
Which hormone is released by the pituitary gland and controls thyroid hormone secretion?
Thyroid Stimulating Hormone (TSH)
How are TRH and TSH secretions controlled?
Negative feedback by T4 and T3
What is thyroid peroxidase enzyme’s role in thyroid hormone biosynthesis?
- Oxidation of iodide
2. Iodination of tyrosyl residues to form mono or di-iodo tyrosyl residues, also known as organification
What is the half life of T3 and T4?
T3 - about a day, T4 about a week
State 5 causes of hypothyroidism
Hashimoto thyroiditis, Iodine deficiency in food, drugs, pituitary failure, hypothalamic failure, congenital conditions
What would be expected of the TSH and T4 levels in a person with primary hypothyroidism?
High TSH, Low T4
What would be expected of the TSH and T4 levels in a person with subclinical hypothyroidism?
Higher than normal TSH, normal T4
Name 5 symptoms of hypothyroidism
Fatigue/lethargy Mental slowness Dry skin Weight gain Irregular menses Hair loss
What drugs are commonly used to manage hypothyroidism?
Levothyroxine and Liothyronine
What precipitates myxedema coma and how would a patient with myxedema coma present?
Myxedema coma occurs as a result of long-standing, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness (infection, heart attack, etc.).
Primary signs and symptoms of myxedema coma are altered mental status andlow body temperature, hypoglycemia, low blood pressure.
How often do we monitor TSH levels after initiating levothyroxine treatment?
6 to 8 weeks
What could cause persistently elevated TSH levels after initiation of treatment?
Poor medication compliance, malabsorption, drud/food interactions, inadequate dosing,
How does cholestyramine (lipid lowering medication) interfere with levothyroxine absorption?
It binds to levothyroxine and interferes with its absorption from the the intestines into the blood stream.
How does estrogen interfere with levothyroxine absorption?
High estrogen promotes synthesis of thyroid binding globulin, which binds to levothyroxine and reduces its free concentration