Drugs used for Peptic Ulcer Disease and Gastroesophageal

Question 1

Mylanta: Action

Answer 1

Create more base gastric secretions to stop pepsinogen from becoming pepsin. Minimum therapeutic pH = 3.5

Question 2

Mylanta: Aluminum containing a/e

Answer 2

constipaion
hypophosphatemia (because aluminum combines with phosphate)

Question 3

Mylanta: Magnesium contaning a/e

Answer 3

hypermagnesmia

Question 4

Mylanta: When should a nurse administer the med?

Answer 4

1-3 hours after meals and at bedtime for greater acid neutralization

Question 5

Patient Teaching: I have heartburn, how can I minimize acid reflux?

Answer 5

HOB elevated
Eat small meals so the stomach isn’t distended
Don’t lie down until more than 1-2 hours after eating
Minimize fat, chocolate, citric juices, coffee and alcohol
Try not to smoke
Avoid obesity and constipation
Don’t take meds at bedtime

Question 6

Patient Teaching: Misoprostol (Cytotec) should be taken only with what other drug and why?

Answer 6

NSAID’s because Misoprostol (Cytotec) is only given to prevent ulcers from NSAIDs

Question 7

Patient Teaching: When should I take Cimetidine?

Answer 7

With your meals or before you go to bed

Question 8

Cimetidine (Tagamet): Action

Answer 8

Decreases the amount, acidity and pepsin content in gastric juices by blocking histamine

Question 9

Cimitidine (Tagamet): It is recommended to take with an antacid but should they be taken together?

Answer 9

No they help relieve pain together but should be taken at different times of the day because the antacid reduces Cimitidines absorption

Question 10

Cimitidine (Tagamet): a/e

Answer 10

gynecomastia

confusion, drowsy, dizzy, diarrhea, headache

Question 11

Cimitidine (Tagamet): Oral administration (when to take it)

Answer 11

If it is a single dose = at bedtime

Multiple oral doses = with meals and at bedtime

Question 12

Omeprazole (Prilosec): Action

Answer 12

Binds to the gastric pump (proton pump inhibitor) to prevent pumping/gastric acid from being made

Question 13

Omeprazole (Prilosec): a/e

Answer 13

basics: nausea, diarrhea and headache

long term high doses: increased bone fracture risk

Question 14

Omeprazole (Prilosec): When to administer the med?

Answer 14

Before you eat. Don’t increase or substitute oral capsules for suspension.

Question 15

Misoprostol (Cytotec): Action

Answer 15

• inhibits gastric secretions and increases mucus and bicarbonate secretions
• inhibits the mucosal damage produced by gastric acids, asprin and NSAIDs.

Question 16

Misoprostol (Cytotec): Black box warning

Answer 16

contraindicated in women who may become pregnant and who are pregnant because it induces abortion, premature birth and/or birth defects

Question 17

Misoprostol (Cytotec): a/e

Answer 17

diarrhea - which can be extremely severe
uterine cramping and vaginal bleeding

n/v and headache

Question 18

Sucralfate (Carafate): What is it used for?

Answer 18

to prevent and treat peptic ulcer disease

Question 19

Sucralfate (Carafate): Action

Answer 19

unknown but it does no inhibit secreation of gastric acid or pepsin or even neutralize it

some think it acts on gastric and duodenal mucosa and healing it from its aluminum contents

Question 20

Sucralfate (Carafate): a/e

Answer 20

not absorbed systemically so there are few:

constipation and dry mouth

Question 21

Sucralfate (Carafate): Administration

Answer 21

one large pill given at LEAST twice a day and shouldn’t be given with gastric acid neutralizers because gastric acid in a way activates it so they decrease it’s action