Drugs To Learn

Question 1

Name 4 drugs that affect NT synthesis and storage:

Answer 1

1. Hemicholinium - prevents choline uptake
2. AMPT - prevents enzyme cascade to make NA
3. Reserpine - prevents storage of NA in vesicle
4. L-DOPA - increases precursor for DA

Question 2

Name 5 drugs that affect release of NT:

Answer 2

1. Guanethidine - inhibits depolarisation prevents NA release
2. Connotoxin - prevents Calcium uptake
3. Clonidine - prevents autoinhibition of NA
4. Botulinum - prevents ACh vesicle fusion
5. Amphetamine - displaces NA

Question 3

Name 3 drugs that affect termination of NT:

Answer 3

1. Neostigmine - inhibits AChE preventing muscle relaxation (anticholinesterase)
2. Fluoxetine (Prozac) - inhibits NA uptake
3. Cocaine/tricyclic antidepressants - inhibit NA uptake

Question 4

Name 5 agonistic drugs with therapeutic use:

Answer 4

1. Salbutamol for asthmatics. Acts on b2 of NA.
2. Phenylephrine for decongestant. Acts on a1 of NA.
3. Bromocriptine for Parkinson’s. Acts on D2 of dopamine.
4. Morphine for pain relief. Acts on mu of enkephalin.
5. Diazepam for anxiety. Acts on A of GABA.

Question 5

Name 5 antagonistic drugs with therapeutic use:

Answer 5

1. Prazosin reduce bp. Act on a1 of NA.
2. Propranolol reduce bp. Act on b of NA.
3. Atracurium is a muscle relaxant. Act on nicotinic of ACh.
4. Atropine has pre-med use. Act on muscarinic of ACh.
5. Trifluoperazine is antipsychotic. Act on D2 of dopamine.

Question 6

Benzodiazepine tranquillisers:

Answer 6

Bind to GABA receptor/chloride ion channels and open channels. Inhibits GABA.

Question 7

Sildenafil (Viagra):

Answer 7

Inhibits breakdown of cGMP which is made by NO.