Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuro III > Drugs To Know For ALS, PD, MS > Flashcards

Drugs To Know For ALS, PD, MS Flashcards

1
Q

Corticosteroid to decrease inflammation
used in acute phase of MS

A

Methyprednisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

SE: weight gain, atrophy, HTN, breakdown of muscle, bones and ligaments

A

Methylprednisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

2 drugs for regular MS

A

Methylprednisone

Dalfampridine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

4 drugs for RRMS

A

Beta 1-a/b
Glatiramer acetate
Fingolimod
Natalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Drug for secondary progressive MS

A

Mitoxanterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

6 drugs for parkinsons

A 
Levodopa + carvidopa 
Ropinorole/prom/roti
Amantidine
Benzotropine/trihexy
Tolcapone/entac
Rasagaline/seleg
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

3 drugs for ALS

A

Riluzole
Nuedexta
Radicava

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Glyburide

A

Reduces swelling after a brain injury

DONT use in elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Interferons are for RRMS

 Reduces intensity and frequency of relapses

A

Beta 1-b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

side effects are fever-like Sx, GI sx, general malaise

A

Beta 1-b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

unique mechanism in the way that it works on the myelin proteins

A

Glatiramer acetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Immunomodulating drug for RRMS
It works by keeping immune cells trapped in your lymph nodes so they can’t reach the
central nervous system (brain and spinal cord)

A

Fingolimod

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SE: weakness, back pain, painin hands/feet, DN, ab pain, headache, hair loss

A

Fingolimod

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Made as a DMT to treat RRMS
o Modifies course of disease

o Molecule VCAM-1 (active molecule in MS) Binds to leukocytes so the drug stops
connection to CNS

A

Natalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Had to have very active Sx and atleast one relapse in the past year to be a candidate for
this med
o IV administered

A

Natalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

blocks the alpha-4 subunit
on integrin molecules located with the vasculature, preventing migration and adhesion
of leukocytes to areas of tissue damage.
 By blocking this interaction, it can reduce the affects that leukocytes can have in
response to tissue damage, such as inflammation.

A

Natalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

SE: abdominal, back, limb, or joint pain, diarrhea, strength and energy loss (fatigue),
headache, depression, muscle cramps, symptoms of the common cold/flu, skin rash or
other infusion related reaction, urinary tract infection, nausea, or an upper/lower
respiratory tract infection

A

Natalizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Used for all kinds of MS except for PPMS

A

Mitoxantrone

19
Q

MOA: interacts with the deoxyribonucleic acid (DNA). The drug intermingles with the
DNA, causing the strands to break apart. This will decrease the effects of the
macrophages, B-cell, and T-cell proliferation and destruction of the myelin sheath2. This
reduction in the proliferation of these cells as well as the reduction of interleukin-2
proteins relate to decreased inflammation that is a result of MS

A

Mitoxantrone

20
Q

12 mg every 3 months and SE is urine color change

A

Mitoxantrone

21
Q

mainly used to regain walking ability
o NOT disease-modifying

A

dalfampridine

22
Q

Use: neurofunctional modifier; improves walking speed and LE strength in patients with
MS

A

dalfampridine

23
Q

Dosage = 10 mg 2x daily
o Immediate Sx = paraestehsia, DNV, anxiety, gait in 3%
o Slow release Sx = falls
o PT considerations = MS will fatigue; watch burning sensations, monitor closely with
vitals

A

dalfampridine

24
Q

inhibit voltage gated potassium channels is this meds MOI

A

dalfampridine

25
Q

Drug combo for PD

o to combat the main symptoms of resting tremor, rigidity, and bradykinetic movements
commonly seen in Parkinson’s

A

Carbidopa/Levodopa

26
Q

Side effects is dyskinesia

A

Carbidopa/Levodopa

27
Q

Dopamine agonist to decrease PD Sx and control fluctuations
 Secondary use: treat restless leg syndrome

A

Ropinorole

28
Q

Side effects of this medication include: worsening dyskinesias, extreme
drowsiness, orthostatic hypotension, hallucinations, swelling of the lower legs,
nausea, vomiting, dry mouth, and impulse control disorders

A

Ropinorole

29
Q

lexi-drug that can be used to treat Parkinson’s Disease and drug-
induced extrapyramidal symptoms
- used to help with tremors in early stages, and reduce dyskinesias in later
stages

A

Amantadine

30
Q

Antiparkinson agent
 Anticholinergic agents for movement disorders
 Used for extrapyramidal disorders
 Centrally active muscarinic antagonist used for Sx of PD

A

Anticholinergic Drugs (trihexyphenidyl; benztropine)

31
Q

Inhibits uptake of dopamine
 MOA: cholinergic antagonist and histamine receptor antagonist
 Possesses both anticholinergic and antihistamine effect

A

Benztropine

32
Q

Side effect is tachycardia

A

Benztropine

33
Q

used to treat the symptoms for idiopathic Parkinson’s disease. It is
usually prescribed if other Parkinson’s drugs are not effective and the patient
has motor fluctuations in symptoms with off times

A

Tolcapone

34
Q

side effects are diarrhea, dyskinesia, dystonia, nausea, sleepy
disturbances/insomnia, muscle cramping, orthostatic instability, orthostatic
hypotension (OH) and syncope
 PT: observe physical appearance or sleepy

A

Tolcapone

35
Q

For PD
 Improves tremors and mobility
 The drug is a monoamine oxidase (MAO) inhibitor, which plays a major role in
the catabolism of dopamine.

A

Rasagaline

36
Q

Side effects of the medication may include “flu like symptoms, headache,
nausea, vomiting, constipation, diarrhea, dry mouth, lack of appetite, abdominal
pain, weight loss, nightmares, joint pain

A

Rasagaline

37
Q

Treats adultonset of diabetes but also this medication could be used for the immediate
treatment of those with brain damage as it has shown do reduce inflammation,
hemorrhage, and vasogenic edema.

A

Glyburide

38
Q

SE: hypoglycemia

o Dont use in elderly

A

Glyburide

39
Q

For ALS

The most common side effects are impact to the gastrointestinal and neuromuscular
system by feeling nausea and weak

A

Riluzole

40
Q

used to treat involuntary outbursts of crying or laughing in people with certain
neurological disorders, including multiple sclerosis and amyotrophic lateral sclerosis
o treats pseudobulbar effect

A

Nuedexta

41
Q

60 mg infusion dose -1 0 days daily and 2 weeks rest

A

Radicava

42
Q

It is thought to act as a free radical scavenger and prevent
oxidative stress damage to neurones.

A

Radicava

43
Q

SE: bruising, gait disturbance, headache, skin inflammation or rash, eczema, respiratory
failure, respiratory disorder, oxygen deficiency, glucose in the urine, and fungal skin
infections

A

Radicava

44
Q

What does radicava have that could cause an allergic rxn esp in ppl with asthma?

A

Sodium bisulfite

Neuro III (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions