Drugs To Know

Question 1

These drugs bind to GABAa receptors and increase GABA activity, lowering seizures
A. Benzodiazepines
B. Barbiturates
C. Tiagabene
D. Vigabatrin

Answer 1

Benzos and barbiturates

C- inhibits gaba transporter
D- inhibits gama aminotransaminase

Question 2

Inhibits gaba transporter reuptake (GAT-1)
A. Benzodiazepines
B. Barbiturates
C. Tiagabene
D. Vigabatrin

Answer 2

Tiagabene (t=transporter)
Inhibiting gaba transporter increases inhibitory effects, reducing seizures

Question 3

A drug that inhibits GABA aminotransferase (GABA-T)

A. Benzodiazepines
B. Barbiturates
C. Tiagabene
D. Vigabatrin

Answer 3

Vigabatrin

Question 4

A non competitive antagonist at the AMPA receptor:

A. Sodium channel blockers
B. Gabapentin
C. Parapanel

Answer 4

Perapanel

Question 5

Changes the conformation of sodium channels to increase the refractory period

A. Sodium channel blockers
B. Gabapentin
C. Parapanel

Answer 5

Sodium channel blockers

Question 6

Inhibits voltage gated sodium channels but has little activity on the GABA receptor:

A. Sodium channel blockers
B. Gabapentin
C. Parapanel

Answer 6

Gabapentin

Question 7

1st generation antipsychotic that acts on D1 and D2 receptors (antagonism) , FAST ON
A. Haloperidol
B. Chloropromazine
C. Clozapine
D. Respiridone

Answer 7

Haloperidol and chloropromazine are both 1st gen antipsychotics

Question 8

A drug that causes high extra pyramidal symptoms

A. Haloperidol
B. Chloropromazine
C. Clozapine
D. Respiridone

Answer 8

C

Question 9

____ causes high extra pyramidal symptoms and _____ and _____ lowers extrapyramidal symptoms (something with movement)

A. Haloperidol
B. Chloropromazine
C. Clozapine
D. Respiridone

Answer 9

Chloropromagazine,

Clozapine and respiradone

Question 10

A monoamine inhibitor that acts like noradrenaline (sympathomimetic monoamine) degraded by MAO, found in cheese
A. Fluoxetine
B. Prozac
C. Psylocibin
D. Tyramine

Answer 10

Tyramine

Question 11

A noncompetative NMDA antagonist, increases glutamate by blocking NMDA receptors on GABA interneurons, increases gene expression and BDNF
A. Psilocybin
B. Tyramine
C. Ketamine
D. Prozac

Answer 11

Ketamine

Question 12

An SNRI that inhibits serotonin and norephinephrine
A. Prozac
B. Psilocybin
D. Ketamine
C. Tyramine
E. Fluoxetine

Answer 12

Fluoxetine

Question 14

Lowersdopamine and noradrenaline
A. Iproniazia
B. Reserpine
C. Resperidone
D. Tyramine

Answer 14

Reserpine

Question 15

A MAO inhibitor that increases monoamines, helps with symptoms of depression
A. Iproniazia
B. Reserpine
C. Resperidone
D. Tyramine

Answer 15

Iproniazia

Question 16

Drug that causes agranulocytes (the loss of white blood cells) by having aunique affinity for D4 receptors
A. Respirodone
B. Clozapine
C. Haloperidol
D. Chloropromazine

Answer 16

Clozapine

Question 17

Drug that causes agranulocytes (the loss of white blood cells) by having aunique affinity for D4 receptors
A. Respirodone
B. Clozapine
C. Haloperidol
D. Chloropromazine

Question 18

A nucleoside analog (uses a fake DNA binding block) that viruses incorportate in their DNA, lacts a 3’ OH group

Answer 18

Acyclovir (anti-herpes drug)

Question 19

Acyclovir must be phosphorylated by ________ to get _________

Answer 19

Thymidine kinase, acyclovir triphosphate

Question 20

How can acycloivir resistance be obtained?
A. Impared production of viral thymidine kinase
B. Presence of 3’OH
C. Altered viral DNA polymerase

Answer 20

A

Question 21

A disease that causes CD4 and T cell levels to drop, loosing immunity
A. Herpes
B. HIV
C. Influeza

Answer 21

Herpes

Question 22

A CCR% receptor anagonist that interferes with HIV binding to T-cell

Answer 22

Maraviroc

Question 23

Mimics natural nucleosides and cause FNA chain termination due to a missing 3’OH group
A. Maraviroc
B. NRTI’s
C. Raltegravir
D. Protease inhibitors

Answer 23

NRTI’s

Question 24

Blocks integrase, which is a viral enzyme that interts its viral genome into the DNA of the host cell

A. Maraviroc
B. NRTI’s
C. Raltegravir
D. Protease inhibitors

Answer 24

Raltegravir

Question 25

Assembly of HIV virions depend on aspartarw proteases, which cleaves precursor proteins. What should we use?

Answer 25

HIV protease inhibitors , which is necessary to block viral maturation

Question 26

lentivirus that affects and lowers the population of CD4 and T cells, lowering immunity and increases the chances of AIDs. begins by attatchment of the virus proteins (gp120) to CD4 and CCR5 receptors on t-cells

Answer 26

HIV

Question 27

a drug combination used to slow or reverse viral rna from HIV a. NRTI's b. entry inhibitors (eg maraviroc) c. INST's (eg raltegravir) d. HAART e. protease inhibitors

Answer 27

HAART

Question 28

lacks a 3'OH group, preventing addition of nucleotides and disrupting DNA synthesis . a small moelcule drug a. NRTI's b. entry inhibitors (eg maraviroc) c. INST's (eg raltegravir) d. HAART e. protease inhibitors

Answer 28

NRTI's (nucleoside reverse transcriptase inhibitors)

Question 29

blocks integrase, an enzyme in which that helps viral enzyme insert its genome on dna a. NRTI's b. entry inhibitors (eg maraviroc) c. INST's (eg raltegravir) d. HAART e. protease inhibitors

Answer 29

INST's (eg raltegravir)

Question 30

used to inhibit aspartate protease , an enzyme in which HIV is dependant on to cleave precursor proteins to cleave the mature core a. NRTI's b. entry inhibitors (eg maraviroc) c. INST's (eg raltegravir) d. HAART e. protease inhibitors

Answer 30

protease inhibitors