Drugs test 2

Question 1

Alendronate

Answer 1

Bisphosphonate oral

Post-menopausal osteoporosis by inhibiting bone resorption

Question 2

Zoledronic acid

Answer 2

Bisphophanate IV

Post-menopausal osteoporosis by inhibiting bone resorption

Question 3

Denosumab

Answer 3

Rank-L inhibitor (activation of osteoclasts)

Post-menopausal osteoporosis with CKD

Question 4

Teriparatide

Answer 4

PTH analog

Severe osteoporosis

Question 5

Raloxifene

Answer 5

Estrogen receptor agonist preventing bone resorption

Osteoporosis with high chances of breast cancer

Question 6

Calcitriol

Answer 6

1-25 Vit D

Hypoparathyroid and CKD

Question 7

Cinacalcet

Answer 7

Calcium mimetic via activates CaSR

Hyperparathyroidism, CKD

Question 8

Glipizide

Answer 8

K+ channel blocker (releases insulin)
Oral
Weight gain hypoglycemia

Question 9

Metformin

Answer 9

decreases hepatic gluconeogenesis
Oral, weight neutral, no hypoglycemia
GI issues

Question 10

Pioglitazone

Answer 10

PPAR agonist (gene transcription)
Oral
fluid retention, weight gain, bone fractures, not in CHF

Question 11

Canagliflozin

Answer 11

Blocks glucose reuptake from urine
Oral, lower BP and MI/stroke, weight loss
osmotic diuresis, UTIs, euglycemic DKA

Question 12

Liraglutide

Answer 12

GLP-1 mimic
Weight loss
nausea, pancreatitis

Question 13

Sitagliptin

Answer 13

Inhibits breakdown of GLP-1
Oral, weight neutral, no hypoglycemia, no nausea
well tolerated

Question 14

Acarbose

Answer 14

Inhibits carb metabolism in gut
Rarely used
GI upset

Question 15

Insulin glargine

Answer 15

Long acting insulin via SC injection

Question 16

NPH insulin

Answer 16

Intermediate acting insulin

Question 17

Insulin lispro

Answer 17

Rapid acting insulin taken before meals