Drugs of the kidneys Flashcards
1
Q
Drugs are metabolised by the _______ to an inactive compound
Can be excreted by the ________
A
liver
kidney
2
Q
What do polar drugs/metabolites require to be excreted?
A
Specialised transporters (mainly PT)
3
Q
Where does tubular secretion mainly occur?
A
Proximal tubule
4
Q
Is penicillin an acid or base?
A
Weak acid
HA ↔ H+ + A-
The A- is removed by an anion transporter
5
Q
Is morphine an acid or base?
A
Morphine is a weak base
B ↔ OH- + BH+
BH+ is removed by a cation transporter
6
Q
What can diuretics be used to treat?
A
Acute pulmonary oedema, heart faliure
Hypertension
7
Q
What are the 5 classes of diuretics?
A
CA inhibitors
Loop
Thiazide
K sparing
Osmotic
8
Q
A
