Drugs Of Abuse MCQ Flashcards
Which of the following drugs works by blocking dopamine, serotonin, and norepinephrine reuptake?
A. LSD
B. Cocaine
C. Amphetamine
D. Ketamine
E. THC
B. Cocaine
Which neurotransmitter is most directly associated with the reinforcing effects of addictive drugs?
A. Acetylcholine
B. GABA
C. Dopamine
D. Glutamate
E. Serotonin
C. Dopamine
Which brain region is most associated with the euphoric “reward” effects of drugs of abuse?
A. Amygdala
B. Hippocampus
C. Nucleus accumbens
D. Prefrontal cortex
E. Cerebellum
C. Nucleus accumbens
Which of the following is classified as a Schedule I drug under U.S. law?
A. Methadone
B. Cocaine
C. LSD
D. Fentanyl
E. Diazepam
C. LSD
What is the mechanism of action of MDMA (ecstasy)?
A. NMDA receptor antagonist
B. Opioid receptor agonist
C. Dopamine transporter blocker
D. Serotonin and norepinephrine releaser
E. GABA-A agonist
D. Serotonin and norepinephrine releaser
What is the primary action of nicotine in the brain?
A. Serotonin reuptake inhibition
B. CB1 receptor activation
C. Muscarinic receptor antagonism
D. Nicotinic acetylcholine receptor agonism
E. GABA-B receptor activation
D. Nicotinic acetylcholine receptor agonism
Which of the following is a common long-term consequence of heavy cannabis use?
A. Seizures
B. Liver fibrosis
C. Amotivational syndrome
D. Parkinsonism
E. Hearing loss
C. Amotivational syndrome
Which drug causes hallucinations via partial agonism at 5-HT2A receptors?
A. MDMA
B. Ketamine
C. Cocaine
D. LSD
E. Heroin
D. LSD
Which drug is known to cause violent behavior and nystagmus during intoxication?
A. Amphetamine
B. LSD
C. Cocaine
D. Phencyclidine (PCP)
E. THC
D. Phencyclidine (PCP)
Which of the following is the mechanism of action of ketamine?
A. Serotonin release
B. NMDA receptor antagonism
C. GABA-A receptor activation
D. Opioid receptor partial agonism
E. Nicotinic receptor desensitization
B. NMDA receptor antagonism
Which inhaled drug of abuse can cause sudden cardiac death via arrhythmia?
A. THC
B. Nitrous oxide
C. Toluene
D. Cocaine
E. Ethanol
C. Toluene
Which of the following is a partial agonist at α4β2 nicotinic receptors used in smoking cessation?
A. Varenicline
B. Bupropion
C. Clonidine
D. Diazepam
E. Naloxone
A. Varenicline
Which of the following best defines tolerance?
A. Enhanced effect after repeated use
B. Withdrawal symptoms after stopping
C. Need for higher doses to achieve the same effect
D. Cross-reaction between two different drugs
E. Psychological craving
C. Need for higher doses to achieve the same effect
Which class of drugs includes substances like glue and paint thinner?
A. Cannabinoids
B. Dissociative anesthetics
C. Inhalants
D. Synthetic opioids
E. Sedative-hypnotics
C. Inhalants
What receptor does THC primarily activate?
A. 5-HT2A
B. GABA-A
C. NMDA
D. CB1
E. D2
D. CB1
A 19-year-old college student presents with agitation, elevated temperature, jaw clenching, and hyponatremia after a party. Which drug is most likely responsible?
A. Cocaine
B. Methamphetamine
C. MDMA
D. LSD
E. Cannabis
C. MDMA
A patient in the ER is combative, with vertical nystagmus, no response to pain, and extreme muscle rigidity. What drug is most likely involved?
A. Methamphetamine
B. PCP
C. LSD
D. MDMA
E. Heroin
B. PCP
A young man presents with hallucinations and reports that he “can hear colors.” He is agitated but oriented. Pupils are dilated. What is the likely substance?
A. Cocaine
B. Methamphetamine
C. LSD
D. Cannabis
E. MDMA
C. LSD
A 16-year-old with poor dentition, xerostomia, and rapid tooth decay is brought in by his parents. Which drug is most likely involved?
A. Cocaine
B. Alcohol
C. MDMA
D. Methamphetamine
E. Heroin
D. Methamphetamine
A woman presents with severe anxiety and restlessness after stopping marijuana use. Which is most likely?
A. THC withdrawal
B. Cocaine crash
C. Alcohol withdrawal
D. Benzodiazepine rebound
E. Opioid withdrawal
A. THC withdrawal
A dental patient smells strongly of chemicals and presents with confusion and slurred speech. Which type of substance is suspected?
A. Cannabinoid
B. Opioid
C. Inhalant
D. Hallucinogen
E. Antidepressant
C. Inhalant
A man who recently quit smoking reports mood swings and increased appetite. Which drug is he likely withdrawing from?
A. Cocaine
B. Nicotine
C. THC
D. Alcohol
E. LSD
B. Nicotine
A patient is brought in confused and lethargic after a night out. Labs show hypothermia and low sodium. Which recreational drug might explain this?
A. Heroin
B. PCP
C. MDMA
D. Cannabis
E. Cocaine
C. MDMA
A 24-year-old presents with conjunctival injection, slowed speech, and increased appetite. He admits to recent drug use. Likely cause?
A. Cocaine
B. THC
C. Amphetamine
D. LSD
E. Ketamine
B. THC
