Drugs of Abuse

Question 1

Describe the mechanism of action of buprenorphine and its clinical use.

Answer 1

It’s a partial agonist at mu receptors used to treat opioid addiction, and is relatively long-acting.

Question 2

Describe the mechanism of action and clinical use of LAAM (levo-alpha-acetyl methadyl).

Answer 2

Same as methadone but lasts longer (mu opioid receptor antagonist). Treats opioid addiction both maintenance and detox (very long acting)

*LAAM is basically a longer acting methadone (LAM)

Question 3

What drug can you give to reduce relapse in cocaine abusers?

Answer 3

Topiramate.

Question 4

How do amphetamine and methamphetamine work?

Answer 4

They enhance synaptic release of DA and NE with weak effects blocking MAO.

Question 5

Describe the mechanism of action of cocaine

Answer 5

Blocks DA reuptake.

Question 6

What neurotransmitter is related to LSD, psilocybin, and DMT?

Answer 6

Serotonin.

Question 7

What neurotransmitters are related to MDMA?

Answer 7

Dopamine and amphetamines.

Question 8

Describe the mechanism of action of dissociatives (e.g. PCP, ketamine).

Answer 8

They inhibit NMDA receptors.