Drugs of abuse

Question 1

Dopamine and addiction

Answer 1

Reward pathway behind addiction, but not entirely as antagonists do not reduce addiction, but knockout mice do not show addiction. Most drugs of abuse increase dopamine levels either directly or indirectly.

Question 2

5HT and drugs of abuse

Answer 2

Responsible for psychotropic effects

Question 3

Cannabanoid CB1

Answer 3

Increases appetite

Antagonist for this could be good anti-obesity drug but side effects currently include pyschosis.