Drugs Non-Linear Flashcards
Non-Linear Area Under the Curve
C – is typical drug that follows PK,
A and B are the same drug given at low and high dose
At low dose enzymes are not saturated, however at high dose follows non linear PK
Staurable Metabolism
A - As metabolism saturates, an increase in dose will not lead to an increase in elimination causing a greater AUC than expected.
Phenytoin, salicyclic acid, valproic acid
Cofactor or enzyme limitation
similar to saturable metabolism
A
Enzyme Induction
Carbazapime
Altered Hepatic Blood FLow
Example
Propranolol
A
Metabolite Inhibition
A
Staurable Transport in Gut Wall
B - Saturate the transporter will not increase the concentration proportionally as you increase the dose
Saturable Intestine Metabolism
A - As you increase the dose the first pass effect will be saturated, and Cp will increase
Drugs with low solubility in GI but high dose
B - As you increase the dose the concentration in the solution remains the same, therefore the absorption remains the same cause
Saturable Gastric GI Decomposition
A - As you increase the dose the decomposition remains the same, therefore the same amount is decomposed and more available to be absorbed
Saturable Plasma Protein
B - As you increase the dose, there is more free drug as no more plasma protein, will also increase the metabolism cause only free drug gets into filtrate and metabolized by liver
Lidocaine, phenytoin, Warfarin
Active Secretion
A - As you increase the dose, the secretion remains the same and excretion does not increase the same
Tubular reabsorption
Bish - As you increase the dose will not get proportional tubular reabsorption, and increase excretion.
Change in urine pH
As you change pH will depend on if it as weak acid or base and the pH values
Billiary Secretion
Aish - Increasing dose can saturate biliary secretion or metabolism so increasing concentration
