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210 > Drugs (Midterm) > Flashcards

Drugs (Midterm) Flashcards

1
Q

CYP2C9

A

Metabolized Warfarin

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2
Q

CYP4F2

A

Reduces Vitamin K

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3
Q

VKORC1

A

Vitamin K recycler

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4
Q

CFTR classes that have not tranpsort

A

III and VI

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5
Q

CFTR gene that is most common

A

F508del, Class II

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6
Q

Ataluren

A

Overcomes the effects of a non-sense mutation and allows for the continued translation of a full length CFTR gene

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7
Q

Kalydeco

A

Opens up the CFTR transporters

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8
Q

Trikafta

A

Combo drug that opens up and it brings CFTR genes to cell surface

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9
Q

What is the ASO ending that we should know?

A

RSEN

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10
Q

What is Exondys 51 or Eteplirsen

A

Fixes the skipping and restores reading frame of DMD gene

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11
Q

What is Spinraza

A

Restores SMN deletion in SMN2 gene and allows the generation of SMN protein

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12
Q

What is PROTACs?

A

Basically bind one end on protein, one end ligase and chew away the protein

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13
Q

What is Imatinib?

A

Targets the BCR-ABL oncogene protein kinase and inhibits it

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14
Q

What are the mechanisms of BCR-ABL mutation mechanisms of resistance?

A
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15
Q

What is Larotrectinib?

A

Block TRK fustion proteins

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16
Q

What is entrecitinib?

A

Blocks ALK TRK ROSI

17
Q

What is Herceptin?

A

Monoclonal antibody that promotes degredation of Her2 receptor and flags it for destruction

18
Q

What is Pertuzamab?

A

Same as herceptin, but it suppresses the Her2 receptor, flags cell for destruction

19
Q

What is T-DM1 MOA?

A

Inhibits mitosis in breast cancer

20
Q

What is Enhertu?

A

Chemo pauload that kills cancer cells Her2

21
Q

What is EGFR1 inhibitors?

A

Treat colon cancer

22
Q

What is resistant to EGFR1 inhibitors?

A

KRAS

23
Q

What is Avastin?

A

Binds VEGF and causes loss of endothelial fenestrations and regression of tumour cells

Improved chemo therapy

24
Q

What is BITE antibodies?

A
25
Q

Main enzyme in liver for drug metabolism?

A

Cyp2d6

26
Q

What is antigen modulation?

A

Endocytosis of surface antigen and hiding them from exposing immune cell antigens

27
Q

What is Cervarix?

A

HPV

28
Q

What is Gardasil

A

HPV

29
Q

What is HBV?

A

HBV vaccine

30
Q

What is the BCG vaccine?

A

Therapeutic vaccine

31
Q

What is SipuleucelT?

A

Therapeutic vaccine

32
Q

What is the following?

A

Therapeutic vaccines

33
Q

What is BCG used for?

A

Treat cancerous tumour in bladder

34
Q

What is CAR?

A

Chimeric antigen receptor targeting a specific antigen in cancer cells

35
Q

What is Car T cell therapy?

A
36
Q

Most common side effect of Car T cell therapy?

A

Cytokine release syndrome

37
Q

What is Ipilimumab?

A

Inhibits PDL1 PDL2 and CTLA-4 (These inactivate the T cell)

38
Q
A

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