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PHARM 2 Exam > Drugs Mentioned in Lecture > Flashcards

Drugs Mentioned in Lecture Flashcards

1
Q

d-Tubocurarine

NOT ON STUDY GUIDE BUT ON LECTURES

A

Class: Nicotinic Antagonist - Nondepolarizing Neuromuscular Blocker

Indications: Previously used for paralysis during surgery.

Contradictions: Should never be used a Toxin

MoA: Competes with ACh at nicotinic cholinergic receptors, notably at the neuromuscular junction. Prevents depolarization of skeletal muscle.

Adverse Effects: Tachycardia, causes hypotension and bronchospasms due to histamine release.

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2
Q

Carbachol

A

Class: Direct Cholinergic Agonist - Choline Ester

Indications: Induce miosis, topical application.

Contrindications: NONE

MoA: Activates ocular M3 cholinergic receptors, not metabolized by corneal AChE so can be used topically.

Adverse Effects: Overdose can lead to cholinergic toxicity

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3
Q

Methacholine

A

Class: Direct Cholinergic Agonist - Choline Ester

Indications: Diagnostic test for asthma.

Contrindications: None

MoA: Activates bronchial M2 & M3 receptors, causing bronchoconstriction in asthmatics.

Adverse Effects: Overdose can lead to cholinergic toxicity

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4
Q

Bethanocol

A

MUSCURINIC SPECIFIC

Class: Direct Cholinergic Agonist - Choline Ester

Indications: Used to treat urinary retention.

Contraindication: NONE

MoA: Activates M3 cholinergic receptors of detrusor muscle, causing contraction.

Adverse Effects: Overdose can lead to cholinergic toxicity

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5
Q

Muscarine

A

Class: Direct Cholinergic Agonist - Plant Alkaloid

indication: No known medical uses.

Contraindications: No known medical uses.

MoA:Specific agonist of muscarinic cholinergic receptors.

Adverse Effects: Cholinergic toxicity.

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6
Q

Pilocarpine

A

Class: Direct Cholinergic Agonist - Plant Alkaloid

Indications: Treating glaucoma or xerostomia, topical or oral.

Contraindications: Only works for open angle glaucoma.

MoA: Cholinergic agonist, higher affinity for muscarinic receptors. Activates M3 receptors of ciliary muscles, causing them to contract and pull open drainage network. Activates M3 receptors of salivary glands.

Adverse Effects: Overdose can lead to cholinergic toxicity

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7
Q

Cevimeline(Evoxac)

A

Class: Direct Cholinergic Agonist - Synthetic Drug

Indications: Treating xerostomia associated with radiation of head & neck or Sjogren syndrome.

Contraindications: None

MoA: Cholinergic agonist that binds to M3 cholinergic receptors of salivary glands. Adverse effects due to M3 activation in sweat glands and eyes.

Adverse Effect: Sweating, visual disturbances due to miosis.

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8
Q

Edrophonium(Tennsilon)

A

Class: Indirect Cholinergic Agonist - Reversible AChE Inhibitor

Indication: Diagnostic test for myasthenia gravis.

Contraindications: Does not treat MG, only works at low doses.

MoA: Competitive AChE inhibitor increases active ACh in the neuromuscular junction. In Myasthenia Gravis low # of muscular receptors, low doses will improve muscle function.

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9
Q

Physostigamine(Mestinon)

A

Class: Indirect Cholinergic Agonist - Reversible AChE Inhibitor

Indications: Treatment of anticholinergic toxicity.

Contraindications: NONE GIVEN

MoA: Competitive AChE inhibitor which increases active Ach in synapses, reversing the effects of anticholinergics. Well-absorbed by gut and crosses BBB.

Adverse Effects: None Given

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10
Q

Neostigmine(Prostigmin)

A

Class: Indirect Cholinergic Agonist - Reversible AChE Inhibitor

Indications: Long term treatment of myasthenia gravis.

Contraindications: None Given

MoA: Competitive AChE inhibitor, very slowly hydrolyzed by AChE, increasing ACh in synapse. Does not cross BBB.

Adverse Reaction: None Given

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11
Q

Pyridostigmine
Not on study guide but in lecture

A

Class: Indirect Cholinergic Agonist - Reversible AChE Inhibitor

Indication: Long term treatment of myasthenia gravis.

Contraindication: None Given

MoA: Competitive AChE inhibitor, very slowly hydrolyzed by AChE, increasing ACh in synapse. Does not cross BBB.

Adverse Effects: Lower incidence of side effects than neostigmine.

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12
Q

Organophosphates

Not on study Guide but in lecture

A

Class: Indirect Cholinergic Agonist - Quasi-reversible AChE Inhibitor

Indications: Treatment of head lice, bioterrorism.

MoA: Binds up AChE, reversible for a while by pralidoxime, but eventually becomes irreversible (aging). Significantly increases ACh in synapse, especially nicotinic sites, causes muscle paralysis by over-depolarization. Lipophilic so it can cross skin and mucous membranes.

Adverse Effects: Very toxic, causes muscle paralysis and respiratory paralysis. To treat toxicity, give cardiopulmonary support, give atropine (ACh antagonist), and give pralidoxime (2-PAM), which can compete for AChE binding.

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13
Q

Sildenafil

A

Class: Indirect Cholinergic Agonist - Phosphodiesterase Inhibitor

Indications: Erection

Contraindications: None given

MoA: Inhibits type-5 phosphodiesterase, which degrades cGMP, increasing cGMP. cGMP promotes vasodilation in response to ACh. Specific for arterioles leading to erectile tissue.

Adverse Effects: None given

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14
Q

Donepezil(Glantamine and rivastigmine)

*NOT ON STUDY GUIDE BUT ON LECTURES

A

Class: Indirect Cholinergic Agonist - Reversible AChE Inhibitor

Indications: Alzheimer’s disease.

Contraindications: NONE

MoA: Competitive AChE inhibitor, crosses the BBB so it increases activity of cholinergic receptors in the brain. Selective for the hippocampus and frontal cortex, supposedly improves memory.

Adverse Effects: None given

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15
Q

Atropine

A

Class: Muscarinic Antagonist - Belladonna Alkaloid

Indication: Mydriasis and blocking accomodation for eye exams. Treatment of bradycardia (IV). Reduces GI spasms and diarrhea. Support for OPP poisoning.

Contraindications: Few uses at clinical doses, synthetic drugs are usually better at various indications.

MoA: Competes with ACh at muscarinic cholinergic receptors, well-absorbed by gut and crosses BBB, so systemic effects. Inhibits actions of PNS, notably in the eyes, heart, and gut.

Adverse Effects: Elevated temperature, decreased sweating, confusion, delirium, flushed face, tachycardia, decreased secretions, dry eyes, thirsty.

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16
Q

Pralidoxime(2-PAM)

A

Class: AChE Reactivator

Indications: Treatment of organophosphate poisoning.

Contraindications: NONE GIVEN

MoA: Displaces organophosphates from AChE, freeing up AChE and decreasing ACh in the synapse, reversing the muscle paralysis.

Adverse Effects: NONE given

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17
Q

Tadalafil (Cialis)

Not in Study guide but given in lecture

A

Class: Indirect Cholinergic Agonist - Phosphodiesterase Inhibitor

Indications: Erection

Contrindications: None Given

MoA: Inhibits type-5 phosphodiesterase, which degrades cGMP, increasing cGMP. cGMP promotes vasodilation in response to ACh. Specific for arterioles leading to erectile tissue.

Adverse Effects: None Given

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18
Q

Vardenafil(Levitra)

A

Class: Indirect Cholinergic Agonist - Phosphodiesterase Inhibitor

Indications: Erection

Contrindications: None Given

MoA: Inhibits type-5 phosphodiesterase, which degrades cGMP, increasing cGMP. cGMP promotes vasodilation in response to ACh. Specific for arterioles leading to erectile tissue.

Adverse Effects: None Given

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19
Q

Scopolamine

A

Class: Muscarinic Antagonist - Belladonna Alkaloid

Indications: Treats motion sickness.

Contraindications: None Given

MoA: Competes with ACh at M1 cholinergic receptors in the brain, specifically from transmission from the vestibular apparatus (ears) to the vomiting center (brainstem). Administered transdermally, can cross skin and BBB.

Adverse Effects: Drowsiness or memory loss.

TRANSDERMAL PATCH FOR MOTION SICKNESS

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20
Q

Hyoscyamine
Not on Study Guide but mentioned in lecture

A

Class: Muscarinic Antagonist - Belladonna Alkaloid

Indications: Reduces spasms caused by disorders of the gut and bladder.

Contraindications: None Given

MoA: Competes with ACh at muscarinic cholinergic receptors, well-absorbed by gut and crosses BBB, so systemic effects. Inhibits actions of PNS, notably in gut and urinary tract.

Adverse Effects: Elevated temperature, decreased sweating, confusion, delirium, flushed face, tachycardia, decreased secretions, dry eyes, thirsty.

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21
Q

Ipratropium(Atrovent)

A

Class: Muscarinic Antagonist - Synthetic

Indications: Treatment of asthma and COPD.

Contraindications: None Given

MoA: Competes with ACh at M3 cholinergic receptors in the lungs, reducing PNS bronchoconstriction. Inhaled and poorly absorbed by the lungs, so effects are local.

Adverse Effects: Minimal side effects.

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22
Q

Tolterodine and Oxybutynin

A

Class: Muscarinic Antagonist - Synthetic

Indications: Treatment of overactive bladder.

Contraindications: None Given

MoA: Competes with ACh at M3 cholinergic receptors in the bladder, preventing detrusor contractions and spasms.

Adverse Effects: None Given

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22
Q

Tolterodine and Oxybutynin

A

Class: Muscarinic Antagonist - Synthetic

Indications: Treatment of overactive bladder.

Contraindications: None Given

MoA: Competes with ACh at M3 cholinergic receptors in the bladder, preventing detrusor contractions and spasms.

Adverse Effects: None Given

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23
Q

Glycopryyolate

NOT ON STUDY GUIDE BUT ON LECTURES

A

Class: Muscarinic Antagonist - Synthetic

Indication: Reducing airway secretions.

Contraindications: None Given

MoA: Competes with ACh at M3 cholinergic receptors in the lungs, reducing their mucosal secretions.

Adverse Effects: None Given

24
Q

Rocuronium(Zemuron)

Pancuronium

A

Class: Nicotinic Antagonist - Nondepolarizing Neuromuscular Blocker

Indications: Used for muscular paralysis during surgery, aids in intubation.

Contradictions: Poorly absorbed from the gut.

MoA: Competes with ACh at nicotinic cholinergic receptors, especially at the neuromuscular junction. Prevents depolarization of skeletal muscle. Effects reversed by providing AChE inhibitors.’

Adverse Effects: Tachycardia, causes hypotension and bronchospasms due to histamine release. Less side effects than d-tubocurarine.

25
Q

Succinylcholine(Suxamethonium)

A

Class: Nicotinic Antagonist - Depolarizing Neuromuscular Blocker

Indications: Rapid induction of muscular paralysis for surgery or emergency intubation.

Contraindications: Difficult to reverse.

MoA: Binds to nicotinic cholinergic receptors at the neuromuscular junction with high affinity, causing continued depolarization of skeletal muscle. Eventually the Na channel inactivation gate cannot open and the NMJ stops producing APs.

Adverse Effects: Initially, transient muscle contractions (fasciculations). Not hydrolyzed by AChE, so effects cannot be easily reversed.

25
Q

Succinylcholine(Suxamethonium)

A

Class: Nicotinic Antagonist - Depolarizing Neuromuscular Blocker

Indications: Rapid induction of muscular paralysis for surgery or emergency intubation.

Contraindications: Difficult to reverse.

MoA: Binds to nicotinic cholinergic receptors at the neuromuscular junction with high affinity, causing continued depolarization of skeletal muscle. Eventually the Na channel inactivation gate cannot open and the NMJ stops producing APs.

Adverse Effects: Initially, transient muscle contractions (fasciculations). Not hydrolyzed by AChE, so effects cannot be easily reversed.

26
Q

Epinephrine

A

Class: Direct Adrenergic Agonist - Catecholamine

Indications: Anaphylaxis, hypovolemic shock.

Contradictions: Hypertension; insufficient for hypovolemic shock without fluid administration.

MoA: Activates adrenergic receptors, acts at a and b receptors equally. Strong b1 effect on heart, b2 vasodilation at low doses but a1 vasoconstriction at high doses. Causes b2 bronchodilation at high doses.

Effects: None Given

27
Q

Norepinephine

A

Class: Direct Adrenergic Agonist - Catecholamine

Indications: Shock: hypovolemic, cardiogenic, septic, and neurogenic.

Contraindications: Hypertension; insufficient for hypovolemic shock without fluid administration.

MoA: Activates adrenergic receptors, acts at a and b receptors, favors b1 to b2. Causes vasoconstriction due to a1 activation. Strongest effect on BP among catecholamines.

Adverse Effects: Reflex bradycardia; can increase mortality in cardiogenic shock due to arrhythmias.

28
Q

Dopamine

A

Class: Direct Adrenergic Agonist - Catecholamine

Indications: Shock: hypovolemic, cardiogenic, septic, and neurogenic.

Contraindications: Hypertension; insufficient for hypovolemic shock without fluid administration.

MoA: Activates dopamine and adrenergic receptors. Prefers D1, then b1, then a receptors. At low doses causes mostly D1 vasodilation, at higher doses causes b1 cardiac activity then a1 vasoconstriction. Does not cross BBB.

Adverse Effects: Can increase mortality in cardiogenic shock due to arrhythmias.

29
Q

Isoproterenol

A

Class: Direct Adrenergic Agonist - Catecholamine(SYNTHETHIC)

indications: Bradycardia, heart blocks, shock.

Contraindications: Hypertension; insufficient for hypovolemic shock without fluid administration.

MoA: Activates adrenergic receptors, primarily b1 and b2 with little a receptor activity. Increases heart rate and contractility, but causes vasodilation so BP unaffected.

30
Q

Dobutamine

A

Class: Direct Adrenergic Agonist - Catecholamine

Indications; Hypovolemic and cardiogenic shock, acute heart failure.

Contraindications: Hypertension; insufficient for hypovolemic shock without fluid administration.

MoA: Activates adrenergic receptors, primarily b1 with some b2 and little a receptor activity. Increases heart rate and contractility, generally increasing BP.

Adverse Effects: Can increase mortality in cardiogenic shock due to arrhythmias.

31
Q

Phenylephrine

A

Class: Direct Adrenergic Agonist - Non-catecholamine

Indications: Treats nasal congestion.

Contraindications: None Given

MoA: Activates a1 adrenergic receptors with selectivity for vessels around nasal mucosa. Causes vasoconstriction of nasal mucosa vessels, opening the airways.

Adverse Effects: None Given

32
Q

Midodrine(ProAmatine)

Not on study Guide but in lecture

A

Class: Direct Adrenergic Agonist - Noncatecholamine

Indications: Treats orthostatic hypotension.

Contraindications: None

MoA: Activates a1 adrenergic receptors causing increase in BP, reduces BP drops associated with orthostatic shifts. Administered as a prodrug, active form produced by liver metabolism.

Adverse Effects: None

33
Q

Albuterol(Proventil)

Not on study Guide but in lecture

A

Class: Direct Adrenergic Agonist - Noncatecholamine

Indications: Acute treatment of asthma and COPD.

Contraindications: None given

MoA: Activates b2 adrenergic receptors causing bronchodilation. Inhaled, causes quick action at bronchioles with acute effects.

Advers: Little side effects since it is inhaled.

34
Q

Terbutaline(Brethine)
Not on study Guide but in lecture

A

Class: Direct Adrenergic Agonist - Noncatecholamine

Indications: Treatment of asthma, management of pre-term labor. Contraindications: None given

MoA: Activates b2 adrenergic receptors causing bronchodilation. Also causes relaxation of uterine smooth muscle, reducing contractions.

35
Q

Clonidine(Catapres)

Not on study Guide but in lecture

A

Class: Direct Adrenergic Agonist - Noncatecholamine

Indications: Management of hypertension

Contraindications: none given

MoA: Activates a2 adrenergic receptors causing systemic vasodilation, reducing BP. Also an imidazoline receptor agonist.

Adverse: None given

36
Q

Clonidine(Catapres)
Not on study Guide but in lecture

A

Class: Direct Adrenergic Agonist - Noncatecholamine

Indications: Management of hypertension

Contraindications: none given

MoA: Activates a2 adrenergic receptors causing systemic vasodilation, reducing BP. Also an imidazoline receptor agonist.

Adverse: None given

37
Q

Cocaine

Not on study Guide but in lecture

A

Class: Indirect Adrenergic Agonist

Indications: Managing local pain during dental procedures.

Contraindications: Hypertension.

MoA: Blocks NET, preventing NE reuptake into presynaptic neuron. Increases NE in synapse causing adrenergic activation. Causes local anesthesia, sympathomimetic effects, and CNS stimulation including euphoria and reward center activation at the nucleus accumbens and ventral tegmental area.

Adverse Effects: Tachycardia and elevated BP. Ischemia and necrosis of nasal mucosa (when insufflated recreationally) due to local vasoconstriction. High risk of addiction.

38
Q

Amphetamine(Also Tyramine)

*Not on study guide but on lecture**

A

Class: Indirect Adrenergic Agonist

Indications: Management of ADD and ADHD.
Contraindications: Hypertension.

MoA: Enters presynaptic knobs of NE neurons through NET. Competes with NE for entry into vesicles through VMAT, preventing NE entry. Cytoplasmic NE increases, causing backwards transport into synapse and prolonging adrenergic receptor activation.

Adverse Effects: Increased BP, various CNS effects, addiction.

39
Q

Ephedrine

A

Class: Mixed Adrenergic Agonist

Indications: Nasal congestion, bronchoconstriction, weight loss.

Contraindications: None given

MoA: Activates both a and b adrenergic receptors by direct and indirect (amphetamine-like) activity. Activation of a1 receptors in nasal mucosa causes vasoconstriction to reduce congestion, activation of b2 receptors causes bronchodilation. Weight loss maybe through b3 activation?

Adverse Effects: Tachycardia and elevated BP. CNS stimulation including sympathomimetic effects.

40
Q

Phenoxybenzamine(Dibenzyline)

Not on study Guide but on lecture

A

Class: Nonselective a-Adrenergic Antagonist

Indications: Hypertension due to pheochromocytoma (catecholamine-secreting adrenal medulla tumor).

Contraindications: Chronic hypertension from other causes.

MoA: Noncompetitive antagonist of a adrenergic receptors (both subtypes), causing long inhibition of their activation. Primarily causes vasodilation due to a1 block, decreasing BP. Prodrug, absorbed from GI in inactive form and metabolized by liver to active form.

Adverse Effects: Also blocks a2 receptors, can cause reflex tachycardia, should be discontinued after tumor removal.

41
Q

Phentolamine(Regitinine)

A

Class; Nonselective a-Adrenergic Antagonist

Indications: Acute hypertension such as pheochromocytoma or adrenergic overdose (epinephrine injection).

Contraindications: Chronic hypertension from other causes.

MoA: Competitive antagonist of a adrenergic receptors (both subtypes), causing rapid and acute inhibition of their activation. Primarily causes vasodilation due to a1 block, reducing BP.

Adverse effects: Also blocks a2 receptors, can cause reflex tachycardia.

42
Q

Prazosin(Minipress)

A

Class: Selective a1-Adrenergic Antagonist

Indications: Originally hypertension, now benign prostate hyperplasia.

Contraindications: None
MoA:Selectively inhibits a1 adrenergic receptors, especially those in the smooth muscle of the urinary tract. Causes relaxation of the urinary sphincter, prostate, and urethra to ease urination which is blocked by BPH.

Adverse Effects: Hypotension, dizziness, and sedation due to excess peripheral dilation (a1 inhibition).

43
Q

Doxazosin(Cardura)

A

Class: Selective a1-Adrenergic Antagonist

Indications: Benign prostate hyperplasia.

Contraindications: None

MoA: Selectively inhibits a1 adrenergic receptors, especially those in the smooth muscle of the urinary tract. Causes relaxation of the urinary sphincter, prostate, and urethra to ease urination which is blocked by BPH.

Adverse Effects: Hypotension, dizziness, and sedation due to excess peripheral dilation (a1 inhibition).

44
Q

Tamsulosin(Flomax)

A

Class: Selective a1-Adrenergic Antagonist

Indications: Benign prostate hyperplasia.

Contraindications: None given

MoA: Selectively inhibits a1 adrenergic receptors, especially those in the smooth muscle of the urinary tract. Causes relaxation of the urinary sphincter, prostate, and urethra to ease urination which is blocked by BPH. More selective to just urinary a1 receptors.

Adverse Effects: Hypotension, dizziness, and sedation due to excess peripheral dilation (a1 inhibition). Side effects less severe than others.

45
Q

Yohimbine

A

Class: Selective a2-Adrenergic Antagonist

Indications: Previously used for erectile dysfunction.

Contraindications: None given

MoA: Selectively inhibits a2 adrenergic receptors, selectively binding to receptors in vasculature leading to erectile tissue.

Adverse: None Given

46
Q

Atenolol(Tenormin)

A

Class: Selective b1-Adrenergic Antagonist

Indications: Treatment of hypertension, angina, and acute MI. Contraindications: None Given

MoA: Selectively inhibits b1 adrenergic receptors, decreasing HR, conduction velocity, and contractility of the heart (cardioselective), thus decreasing CO and BP.

Side effects from b2 block only at high doses.

47
Q

Esmolol(Brevibloc)

Not on study guide but in lecture

A

Class: Selective b1-Adrenergic Antagonist

Indications: Treatment of acute hypertension or supraventricular tachycardia.

Contraindications: Poor for chronic hypertension.

MoA; Selectively inhibits b1 adrenergic receptors, decreasing HR, conduction velocity, and contractility of the heart (cardioselective), thus decreasing CO and BP.

Side effects from b2 block only at high doses.

48
Q

Metoprolol(Lopressor)

A

Class: Selective b1-Adrenergic Antagonist

Indications: Treatment of hypertension, angina, and acute MI.

Contraindications: none given

MoA: Selectively inhibits b1 adrenergic receptors, decreasing HR, conduction velocity, and contractility of the heart (cardioselective), thus decreasing CO and BP.

Side effects from b2 block only at high doses.

49
Q

Propranolol

A

Class: Nonselective b-Adrenergic Antagonist

Indications: Treatment of hypertension, angina, arrhythmias, migraines, and pheochromocytomas.

Contraindications:

MoA: Inhibits b adrenergic receptors (both subtypes), b1 block causes therapeutic effects including decreasing cardiac output, decreasing renin secretion, and decreasing BP.

Adverse Effects: b2 block causes adverse effects, including bronchoconstriction and decreased glycogenolysis (hypoglycemia).

50
Q

Timolol

A

Class: Nonselective b-Adrenergic Antagonist

Indications: Treatment of hypertension, migraines, and glaucoma.

Contraindications: None Given

MoA: Inhibits b adrenergic receptors (both subtypes), b1 block causes therapeutic effects including decreasing cardiac output, decreasing renin secretion, and decreasing BP. Decreases aqueous humor production and thus intraocular pressure.

Adverse Effects: b2 block causes adverse effects, including bronchoconstriction and decreased glycogenolysis (hypoglycemia).

51
Q

Carvedilol(Coreg)

A

Class: a & b-Adrenergic Antagonist

Indications: Management of MI, treatment of hypertension.

Contraindications: None Given

MoA: Inhibits a1, b1, and b2 adrenergic receptors, causing vasodilation and decreased heart rate and contractility. This reduces the effects of MI and reduces BP. Also has antioxidant effects which reduce apoptosis and protect the heart from inflammation and reperfusion damage.

Adverse Effects: None Given

52
Q

Labetalol(Trandate)

A

Class: a & b-Adrenergic Antagonist

Indications: Treatment of hypertension.

Contraindications: Angina pectoris.

MoA: Inhibits a1, b1, and b2 adrenergic receptors and has antioxidant effects, causing vasodilation and decreased heart rate and contractility, reducing BP.

Adverse Effects: Intrinsic sympathomimetic activity (ISA) causing partial agonist activity at b receptors, reducing risk of bradycardia, but increasing MI risk in patients with angina.

53
Q

Glycopyrrolate

Not on Study Guide but in Lecture

A

Class: Muscarinic Antagonist - Synthetic

Indications: Reducing airway secretions.

MoA: Competes with ACh at M3 cholinergic receptors in the lungs, reducing their mucosal secretions.

54
Q

Hexamethonium

Not on Study Guide but in lecture

A

Class: Nicotinic Antagonist - Ganglionic

Indication: Treatment of hypertension.

MoA: Blocks nicotinic cholinergic receptors in the ANS ganglia (postganglionic cell bodies), reducing ANS signal transmission. Primarily targets SNS to lower BP, but can also target PNS.

Adverse Effects: Decreased PNS activity.

55
Q

Nicotine

A

Class: Direct Cholinergic Agonist - Plant Alkaloid

Indications: Aids in smoking cessation.

Contraindications: Don’t give to people not addicted to nicotine.

MoA: Specific agonist of nicotinic cholinergic receptors, causes strong response in addiction center in brain.

Adverse Effects: Highly addictive, only give to reduce withdrawals of current addiction.

56
Q

Pirenzepine

Not on study Guide but in lecture

A

Class: Muscarinic Antagonist - Synthetic

Indication: Peptic ulcer treatment.

MoA: Competes with ACh at M3 cholinergic receptors in the stomach, reducing gastic juice secretions and decreasing acidic aggravation of the peptic ulcer.

PHARM 2 Exam (2 decks)

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