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MCQs - psychiatry > Drugs - mechanisms of action > Flashcards

Drugs - mechanisms of action Flashcards

1
Q

Mirtazapine

A 
NaSSA
5HT2 antagonist
5HT3 antagonist
H1 antagonist
A1 antagonist
A2 antagonist
Muscarinic antagonist
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2
Q

Venlafaxine

A

SNRI

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3
Q

Duloxetine

A

SNRI

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4
Q

Reboxetine

A

NaRI

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5
Q

St John’s Wort

A

Weak MAOi
Weak SNRI
Weak SSRI

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6
Q

Trazodone

A

SARI
5HT1A - antagonist, blocks SERT (antidepressant effect)
5HT2A - antagonist, blocks SERT
5HT2C - antagonist, blocks SERT

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7
Q

Moclobemide

A

Reversible MAOi

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8
Q

Agomelatine

A

MT1 agonist
MT2 agonist
5HT2C antagonist

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9
Q

Bupropion

A

NDRI

Nicotinic Ach antagonist

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10
Q

Donepezil

A

Reversible AChEi

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11
Q

Rivastigmine

A

Reversible AChEi

Butyrylcholinesterase inhibitor

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12
Q

Galantamine

A

Reversible AChEi

Binds allosterically to the nicotinic acetylcholine receptor

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13
Q

Memantine

A

Non-competitive NMDA antagonist

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14
Q

Valproate

A

GABA agonist

NMDA antagonist

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15
Q

Gabapentin

A

Binds to voltage-activated calcium channels

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16
Q

Topiramate

A

GABA agonist
NMDA antagonist
Na+ channel stabiliser

17
Q

Carbamazepine

A

Na+ channel stabiliser

18
Q

Phenytoin

A

Na+ channel stabiliser

19
Q

Lamotrigine

A

NMDA antagonist

Na+ channel stabiliser

20
Q

Pregabalin

A

Potent ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the CNS

21
Q

Benzodiazepines

A

GABA-A agonist

22
Q

Z-drugs

A

GABA-A agonist

23
Q

Buspirone

A

5HT1A partial agonist

24
Q

Flumazenil

A

GABA-A antagonist

25
Q

Amisulpride

A

D2 antagonist

D3 antagonist

26
Q

Olanzapine

A

Dopamine antagonist

5HT2 antagonist

27
Q

Aripiprazole

A

Partial agonist D2
Partial agonist 5HT1A
5HT2A antagonist

28
Q

Clozapine

A

Dopamine antagonist (esp D4)
5HT1A partial agonist
5HT2 antagonist

29
Q

Lurasidone

A 
D2 antagonist 
5HT2A antagonist
5HT7 antagonist 
Alpha blocker
Partial agonist 5HT1a
30
Q

Ketamine

A

NMDA antagonist

31
Q

Clonidine

A

A2 agonist

32
Q

Buprenorphine

A

Partial mu-opioid agonist

33
Q

Naloxone

A

Pure opioid antagonist

34
Q

Atomoxetine

A

NaRI

35
Q

Varenicicline

A

Nicotinic receptor partial agonist

36
Q

Disulfiram

A

Irreversible binding to acetaldehyde dehydrogenase/

37
Q

Acamprosate

A

Glutamate receptor antagonist

GABA-A agonist

38
Q

Selegiline

A

Irreversible MAOi

39
Q

Sildenafil

A

Inhibits cGMP-specific PDE5

MCQs - psychiatry (2 decks)

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