Drugs (length/days) Flashcards
Romidepsin (Istodax)
“IV infusion: over 4 hours
Cycle: 14 mg/m2 IV over 4 hours on days 1, 8, and 15 repeated every 28 days until disease progression.”
Rituximab-pvvr (Ruxience)
“IV infusion:
First dose: initiate at 50 mg/hr. If no reaction, increase by 50 mg/hr every 30 min
to a maximum of 400 mg/hr.
Subsequent doses: initiate at 100 mg/hr. If no reaction, increase by 100 mg/hr
every 30 min to a maximum of 400 mg/hr.
Stop or slow infusion if reaction occurs; depending on severity, infusion may be
restarted at a minimum of 50% reduction in rate after resolution of symptoms.
Rapid infusion protocol may be used if patient tolerated first dose.”
ABATACEPT (Orencia)
“IV Infusion: over 30 minutes
Cycle: C1 days 1, 15, 29 then every 4 weeks.
SQ: room temperature for 30 minutes prior to injecting
Cycle: weekly “
ETOPOSIDE (toposar; VP-16)
“IV infusion: over 30-60 min doses > 500 mg, infuse over 60 min
Cycles: (vary by indication)
SCLC (with Cisplatin):days 1-3 every 21 days; Testicular: (BEP) Days 1-5 every 21 days “
FILGRASTIM-SNDZ (Zarxio)
”
Subcut Injection
Cycle: Administer at least 24 hr after chemotherapy”
“ADO-TRASTUZUMAB EMTANSINE (KADCYLA)
“
“IV infusion: over 90 min (initial dose) or over 30 min (subsequent doses)
Cycle: every 3 weeks “
ROMIPLOSTIM (NPlate)
1 mcg/kg/week subcutaneously initially; adjust dose based on platelet counts only. Do not exceed the maximum weekly dose of 10mcg/kg.
- AZACITIDINE (VIDAZA)
“Allow up to 30 minutes to warm to RT if refrigerated.
SQ: Mix well before administration by inverting syringe 2-3 times and gently rolling between palms. Administer in upper arm, upper thigh and abdomen.
Rotate injection sites
IV infusion: over 10-40 min. (Must complete infusion within 1 hr of reconstitution)
“
LEUCOVORIN CALCIUM (Wellcovorin)
“IV push: administer no faster than 160 mg/min (rate limited by calcium content)
IV infusion: over 90-120 min or see protocol for infusion rate
“
IRINOTECAN LIPOSOME (Onivyde)
Cycle: Every 2 weeks
SACITUZUMAB GOVITECAN-hziy (Trodelvy)
“10mg/kg once weekly and DAy 1 and 8 of a 21 day treatment cycle.
First infusion: Over 3 hours.
Subsequent infusions: 1-2 hours if prior infusions were well tolerated. “
TRASTUZUMAB (Herceptin)
“IV infusion:
Loading dose (8 mg/kg): infuse over 90 min
Weekly doses (2 mg/kg): infuse over 30 min
Multi-week doses (4-6 mg/kg): infuse over 30-60 min. every 3 weeks.
”
SOMATULINE DEPOT (Lanreotide)