Drugs in red Flashcards

1
Q

Chlorpromazine (Thorazine)

A
  • First generation antipsychotic
  • Low affinity for D2 receptors, so higher dose is needed
  • Originally developed as a pre anesthetic medication
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2
Q

Adasuve (Loxapine)

A
  • First generation antipsychotic
  • Inhaler
  • Used in treatment of acute agitation in pts with bipolar disorder or schizophrenia
  • Onset: 10 min
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3
Q

Haloperidol (Haldol)

A
  • First generation antipsychotic
  • Less sedative
  • Less ANS side effects
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4
Q

Clozapine (Clozaril)

A
  • OG second generation antipsychotic
  • Has all of the black box warnings
  • Requires frequent monitoring
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5
Q

SGAs with high incidence of weight gain/diabetes/dyslipidemia

A
  • Clozapine (Clozaril)

- Olanzapine (Zyprexa)

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6
Q

SGAs with moderate incidence of weight gain/diabetes/dyslipidemia

A
  • Quetiapine (Seroquel)
  • Risperidone (Risperdal)
  • Iloperidone (Fanapt)
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7
Q

SGAs with low incidence of weight gain/diabetes/dyslipidemia

A
  • Aripiprazole (Abilify)
  • Ziprasidone (Geodon)
  • Lurasidone (Latuda)
  • Paliperidone (Invega)
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8
Q

Brexpiprazole (Rexulti)

A
  • Partial agonist of 5HT1A
  • Partial agonist of D2
  • Antagonist of 5HT2A/HT2B
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9
Q

Cariprazine (Vraylar)

A
  • Partial agonist of 5HT1A
  • Partial agonist of D2
  • Antagonist of 5HT2A
  • Partial antagonist at D2
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10
Q

Quetiapine (Seroquel) Abuse/ off label use

A
  • Not a controlled substance
  • Off label use for insomnia
  • Off label use for anxiety disorder
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11
Q

What drug class is Fluoxetine (Prozac)

A

-SSRI

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12
Q

What drug class is Venlafaxine (Effexor)

A

-SNRI

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13
Q

What drug class is Trazodone (Desyrel)

A

-SGA

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14
Q

What drug class is Phenylzine (Nardil)

A
  • MAOI

- Do NOT combine with TCA or SSRI

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15
Q

List some 3 drugs that can be used to increase either NE or 5HT

A
  • Trazodone (Desyrel)
  • Mirtazapine (Remeron)
  • Vilazodone (Viibryd)
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16
Q

Lithium MoA

A

-Depletes inositol

17
Q

Diazepam (Valium) MoA

A
  • Potentiates GABA hyper polarization

- Acts on GABA(a) receptors``

18
Q

Baclofen (Lioresal) MoA

A
  • Presynaptic GABA(b) receptors
  • Decreasing calcium influx
  • Decreasing glutamate release
  • Postsynaptic GABA(b)
  • Increasing K+ efflux (hyper-polarizing)
  • Do NOT discontinue abruptly
19
Q

Tizanidine (Zanaflex) MoA

A
  • Presynaptic inhibitor of motor neuron hyperactivity
  • Agonist of alpha 2a
  • Decreases calcium flow into presynaptic neuron
  • Decreasing glutamate release
20
Q

Dantrolene (Dantrium) MoA

A
  • Inhibits sarcoplasmic reticulum RyR1
  • Inhibits calcium release
  • Inhibiting contractions
  • No effect on cardiac/smooth muscle (uses RyR2)
21
Q

Fomepizole (Antizol) MoA

A
  • Competitive inhibitor of alcohol dehydrogenase

- Can use in combination with hemodialysis and general supportive care