Drugs in red Flashcards
Chlorpromazine (Thorazine)
- First generation antipsychotic
- Low affinity for D2 receptors, so higher dose is needed
- Originally developed as a pre anesthetic medication
Adasuve (Loxapine)
- First generation antipsychotic
- Inhaler
- Used in treatment of acute agitation in pts with bipolar disorder or schizophrenia
- Onset: 10 min
Haloperidol (Haldol)
- First generation antipsychotic
- Less sedative
- Less ANS side effects
Clozapine (Clozaril)
- OG second generation antipsychotic
- Has all of the black box warnings
- Requires frequent monitoring
SGAs with high incidence of weight gain/diabetes/dyslipidemia
- Clozapine (Clozaril)
- Olanzapine (Zyprexa)
SGAs with moderate incidence of weight gain/diabetes/dyslipidemia
- Quetiapine (Seroquel)
- Risperidone (Risperdal)
- Iloperidone (Fanapt)
SGAs with low incidence of weight gain/diabetes/dyslipidemia
- Aripiprazole (Abilify)
- Ziprasidone (Geodon)
- Lurasidone (Latuda)
- Paliperidone (Invega)
Brexpiprazole (Rexulti)
- Partial agonist of 5HT1A
- Partial agonist of D2
- Antagonist of 5HT2A/HT2B
Cariprazine (Vraylar)
- Partial agonist of 5HT1A
- Partial agonist of D2
- Antagonist of 5HT2A
- Partial antagonist at D2
Quetiapine (Seroquel) Abuse/ off label use
- Not a controlled substance
- Off label use for insomnia
- Off label use for anxiety disorder
What drug class is Fluoxetine (Prozac)
-SSRI
What drug class is Venlafaxine (Effexor)
-SNRI
What drug class is Trazodone (Desyrel)
-SGA
What drug class is Phenylzine (Nardil)
- MAOI
- Do NOT combine with TCA or SSRI
List some 3 drugs that can be used to increase either NE or 5HT
- Trazodone (Desyrel)
- Mirtazapine (Remeron)
- Vilazodone (Viibryd)
Lithium MoA
-Depletes inositol
Diazepam (Valium) MoA
- Potentiates GABA hyper polarization
- Acts on GABA(a) receptors``
Baclofen (Lioresal) MoA
- Presynaptic GABA(b) receptors
- Decreasing calcium influx
- Decreasing glutamate release
- Postsynaptic GABA(b)
- Increasing K+ efflux (hyper-polarizing)
- Do NOT discontinue abruptly
Tizanidine (Zanaflex) MoA
- Presynaptic inhibitor of motor neuron hyperactivity
- Agonist of alpha 2a
- Decreases calcium flow into presynaptic neuron
- Decreasing glutamate release
Dantrolene (Dantrium) MoA
- Inhibits sarcoplasmic reticulum RyR1
- Inhibits calcium release
- Inhibiting contractions
- No effect on cardiac/smooth muscle (uses RyR2)
Fomepizole (Antizol) MoA
- Competitive inhibitor of alcohol dehydrogenase
- Can use in combination with hemodialysis and general supportive care
