Drugs in Pregnancy Labor and Lactation Flashcards

1
Q

Factors that influence drugs’ passage across placenta

A
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2
Q

How drugs affect fetus

A
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3
Q

How drugs affect the fetus depends on

A
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4
Q

Stages at which fetus is affected

A
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5
Q

Effect of drugs administered during implantation stage

A

May lead to failure of pregnancy

eg. Methotrexate (anticancer drug)

Alcohol

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6
Q

Effect of drugs adminstered during organogenesis

A
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7
Q

Teratogenicity of thalidomide

A
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8
Q

Teratogenicity of Retinoids

A

Skeletal deformities (strong)

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9
Q

Teratogenicity of methotrexate

A

Cleft palate/hydrocephalus

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10
Q

Teratogenicity of Phenytoin

A
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11
Q

Teratogenicity of Valproate

A
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12
Q

Teratogenicity of Warfarin

A

Nasal hypoplasia

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13
Q

Teratogenicity of diethylstilbestrol

A

Adenocarsinoma of vagina in teenage years of the daughter

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14
Q

Teratogenecity during the G and D stage

A
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15
Q

Drugs given at end of pregnancy ie before or during labor

A
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16
Q

Effect of Asprin

17
Q

Effects of Sulfonamides

18
Q

Effect of BZDs and Opiates

19
Q

More teratogenic drugs

20
Q

FDA RISK CATEGORIES

21
Q

Effect of Pregnancy on Distribution

22
Q

Effect of drug on elimination

23
Q

Common chronic conditions in pregnancy

24
Q

Concerns with antiepileptic drugs

25
Factors controlling transfer of drug to breast milk
* Lipid solu * MW * Ionization * Blood flow **Note:** most enter blood but at small amounts
26
Drugs safe during breast feeding
27
Drugs avoided during breast feeding
28
Minimizing effects during breast feeding
* Avoid if possible * Safest effective medicine * LOWEST possible dose * Take immediately after breast feeding * Lactation risk guidelines