Drugs in Pregnancy

Question 1

Paroxetine associated with?

Answer 1

1. Possible cardiac anomalies- not rec in preg

2. If exposed 1st tri -> fetal ECHO

Question 2

SSRI exposure?

Answer 2

In late pregnancy can lead to w/dr

Question 3

TCA exposure?

Answer 3

1. Limb anomalies

Question 4

Lithium associations?

Answer 4

1. Ebstein’s anomaly, need ECHO of 1st tri exposure

2. Monitor Li levels

Question 5

Best bipolar med in preg?

Answer 5

Lamotrigine- best safety profile of the mood stabilizers

Question 6

Worst anti-epileptic?

Answer 6

Valproate - assoc:
1. NTD
2. craniofacial anom
3. limb anom
4. CV anom
?Aspergers? Mental delay

Question 7

Carbamezepine assoc?

Answer 7

1. facial anom

2. Fingernail hypoplasia

Question 8

Benzo’s assoc?

Answer 8

1. floppy infant syndr

2. Oral cleft (0.01% incr risk)