Drugs In Cholinergic Pharm

Question 1

What is the function of hemicholinium?

Answer 1

Inhibits the rate limiting step in ACh synthesis by inhibiting the reuptake of choline into the neuron

Question 2

Function of vesamicol

Answer 2

Inhibit transport of ACh into VAChT

Question 3

Botulinium toxin (botox) function

Answer 3

Inhibit the release of ACh from VAChT

Question 4

Function of pralidoxime

Answer 4

It reactivates AChE after inhibition

Question 5

Function of atropine

Answer 5

• Non-selective muscarinic receptor inhibitor
• antagonist

Question 6

Function of bathenacol

Answer 6

• agonist
• binds to M3 receptor
• longer acting than ACh because it is slowly hydrolysed by AChE
• treats urinary retention

Question 7

Function of pilocarpine

Answer 7

• eye drop for glaucoma
• M3 receptor agonist
• hydrolysed slowly
• constriction of ciliary body -> clearer passage for aqueous humour to flow through canal of Schlemm -> decrease intra-ocular pressure

Question 8

Succinylcholine

Answer 8

• not hydrolysed by AChE
• long lasting action on NMJ
• competitive depolarising blocker acting post-synaptically on the end-plate of the NMJ
• cause flaccid paralysis

Question 9

Pancuronium

Answer 9

• competitive non-depolarising neuromuscular blocking drug -> inhibits muscle contraction
• its effects can be overcome by adding AChE inhibitors when pancuronium is in small doses

Question 10

Types of anticholinesterases

Answer 10

Edrophonium (short),
medium acting: Neostigmine, pyridostigmine, physostigmine
Long acting: parathion, malathion