Drugs In Angina Pectoris

Question 1

angina of effort or classic angina associated with atheromatous plaques that partially occlude 1 or more coronary arteries, 90% of angina cases?

Answer 1

atherosclerotic angina

Question 2

rest angina, variant angina or prinzmetal angina, responsible for less than 10% of cases, involves reversible spasm of coronaries, usually at site of atherosclerotic plaque

Answer 2

vasospastic angina, may deteriorate into unstable angina

Question 3

unstable/crescendo angina, acute coronary syndrome, increased frequency and severity of attacks that result from a combination of atherosclerotic plaques, platelet aggregation and vasospasm

Answer 3

unstable angina, immediaye precursor of myocardial infarction.

Question 4

how to correct angina?

Answer 4

defect that causes anginal pain is inadequate coronary oxygen delivery relative to the myocardial oxygen requirement.

increase oxygen delivery, reduce oxygen requirement.

Question 5

vasodilators?

Answer 5

nitrates, calcium channel blockers

Question 6

nitrates (amyl nitrate) class and moa?

Answer 6

ultrashort acting nitrate, release nitric oxide (NO), increase cGMP (cyclic guanosine monophosphate), and relaxes smooth muscle, especially vascular.

Question 7

amyl nitrate uses and side effects?

Answer 7

cyanide poisoning, reflex tachy, orthostatic hypotension, headache, methemoglobinemia.

Question 8

which portion of electron transp chain affected by cyanide?

Answer 8

complex IV (cytochrome oxidase) of the electron transpory chain.

Question 9

what is the antidote for cyanide poisoning?

Answer 9

inhaled amyl nitrite + IV sodium intrite + IV sodium thiosulfate

Question 10

due to occupational exposure to nitrates?

Answer 10

monday disease, alternating development of tolerance (during the work week) and loss of tolerance (over the weekend).every monday

Question 11

nitroglycerin simD? class?

Answer 11

isosorbide dinitrate, isosorbide mononitrate. short acting nitrate

Question 12

nitroglycerin MOA? uses?

Answer 12

release nitric oxide (NO), inc cGMP, relaxes smooth muscles, especially vascular. Angina, ACS

Question 13

Nitroglycerin SE? other notes

Answer 13

reflex tachycardia, orthostatic hypotension, headache, tolerance (transdermal). dangerous hypotension with PDE inhibitors.

Question 14

why do patients taking bitrates experience throbbing ha?

Answer 14

due to meningeal blood vasodilation.