Drugs for Skin and Eyes (no ears)

Question 1

SKIN: Isotretinoin (Accutane)
(retinoid)

Answer 1

-for severe cystic acne
-MOA: inhibit sebaceous gland, antikeratinizing, anti-inflammatory
-PO

Question 2

accutane adverse

Answer 2

-common: nosebleeds, inflamed lips/eyes, dry or itch skin/nose/mouth
-avoid sun
-rare: depression
-can impact liver: get LFTs

Question 3

accutane contraindications and education

Answer 3

-pregnancy category X
(rule it out before start and test every month)
(be on 2 forms of birth control 1 month before start, during, and after)
-hazadorous drug: safe handling

Question 4

Topical administration

Answer 4

-to prevent systemic absorption, DONT apply on:
-large abraded/denuded areas
-medicated skin covered with occlusive dressing
-solvent where drug is added
-no apply heat

-wear gloves, minimal exposure

-monitor for severe itching, swelling, burning, open blisters

Question 5

EYES: Timolol (Timoptic)

Answer 5

-treat glaucoma –> MOA: decrease production of aqueous humor to lower IOP
-WILL need to take it lifelong
-is a non selective beta blocker

-common adverse: stinging on application, bronchoconstriction and drop BP, decrease BG

-safe admin: light pressure to lacrimal sac 1min

-bc nonselective: monitor BP/HR, BG levels
-HOLD: if COPD/asthma, diabetic, hypotensive