Drugs for Mood P1

Question 1

Sertraline

Answer 1

inc GI upset- Diarrhea
Less prolonged QT
More Drowsy, higher insomnia

Question 2

Citalopram, escitalopram

Answer 2

Prolonged Qt
Least inhibited of hepatic CYPs (good for alcoholic patients bc not hard on liver)

Question 3

Fluvoxamine

Answer 3

Shortest half-like 15hours
Somnolence(sleepy)
CYP inhibitor

helpful for OCD

Question 4

Fluoxetine

Answer 4

Longest half-like 3 days
Higher insomnia
DONT take with tamoxifen

must wait 5 weeks before starting MAOI

Question 5

Paroxetine

Answer 5

Anticholinergic SE
higher risk of orthostatic hypotension, weight gain, and sexual dysfunction
CYP inhibitor
DONT take with tamoxifen

Question 6

Venlafaxine

Answer 6

N/V
HTN

Question 7

Desvenlafaxine

Answer 7

Less HTN than venlafaxine

Question 8

Duloxetine

Answer 8

Only SNRI with hepatic CYP inhibitor
Least HTN effects
indication for chronic pain relief

Question 9

Milnacipran, Levomilnacipran

Answer 9

Pseudo-anticholinergic SE
Urinary retention, constipation, dry mouth
Milnacipran for pain relief (fibromyalgia)

Question 10

Bubpropion

Answer 10

Dry mouth
Insomnia
Seizure
CI with seizure disorder, anorexia, bulimia

Question 11

Mirtazapine

Answer 11

Dry mouth
Drowsiness
Sedation
Increase appetite (helpful for elderly patients trying to gain weight)
Sexual dysfunction

No hepatic CYP inhibition

helpful for patients with depressive symptoms that are also suffering from insomnia

Question 12

Ketamine/Esketamine

Answer 12

Ketamine (IV)
Esketamine (nasal)

HTN
Tachycardia
N/V
long term-Abuse/addiction
Neuro, bladder, hepatotoxicity

CI: Aneurysmal disease, AV malformation, Hx of ICH, inability to tolerate increase in BP
DI: CNS depressants, nasal sprays

Question 13

MAOIs (TIPS)

Answer 13

HypoTN
Urinary hesitancy
Myoclonic jerks
Edema
HTN crisis with tyramine food

CI: Pheochromocytoma(benign tumor in adrenal gland)
Hepatic/renal impairment
CVD

SE include hypertensive crisis when consuming foods with tyramine (aged cheese, soy sauce, cured meats, tap beer, tofu, sauerkraut)

Question 14

List the 4 MAOIs?

Answer 14

Tranylcypromine
Isocarboxazid
Phenelzine
Selegiline available orally or transdermally, can be used for parkinsons disease

Question 15

Nefazodone

Answer 15

BBW: hepatoxictiy, hepatic cytochrome enzyme inhibition

Dizziness, drowsiness, insomnia
Xerostomia (dry mouth)
HypoTN

CI: HX of liver disease
Elevated liver enzymes

Question 16

Trazodone

Answer 16

Sedation
Dry mouth
N/C
Sexual dysfunction
Priapism
Cardiac arrhythmias
Weight neutral treatment

Question 17

Vilazodone

Answer 17

HA
N/D
Sexual dysfunction
Fast onset

Question 18

Vortioxetine

Answer 18

Dizziness
N/V/D/C
Sexual dysfunction
Fast onset

Question 19

TCAs (A DICT) (NPD)

Answer 19

Anticholinergic
Drowsiness
Sexual dysfunction
Weight gain
Diaphoresis
Tremor
Cardiotoxicity(prolonged QT)
Can die from overdose

Question 20

TeCAs

Answer 20

Less anticholinergic than TCAS but more antihistamine

For refractory or atypical depression

Question 21

Lithium

Answer 21

For bipolar/unipolar depression

Question 22

All MOAIs TIPS?

Answer 22

Tranycypromine
Isocarboxazid
Phenelzine
Selegiline

Question 23

TCAs (ADICT) (NPD)

Answer 23

Amitriptyline
Doxepin
Imipramine
Clomipramine
Trimipramine

Nortriptyline
Protriptyline
Desipramine

Question 24

TeCAs (MA)

Answer 24

Maprotiline
Amoxapine

Question 25

Antipsychotics
A queen bee slays

Answer 25

Aripiprazole
Quetiapine
Brexipipirazole
Symbyax