Drugs for Inflammation

Question 1

how do glucocorticoids work in regard to inflammation?

Answer 1

inhibit Arachadonic Acid release

Question 2

how do NSAIDS work in regard to inflammation?

Answer 2

inhibit COX (1&2)

Question 3

3 indications for NSAIDS

Answer 3

anit-inflam, analgesic, anti-pyretic

Question 4

4 adverse effects of NSAIDS

Answer 4

gastro-intestinal, increase bleeding time, renal & pulmonary

Question 5

explain why NSAIDs cause GIT problems

Answer 5

inhibits mucosal secretion of PGE2 and PGI2.

PGE2 induces mucus secretion, inhibits gastric acid secretion

Question 6

explain how NSAIDs cause increase bleeding time

Answer 6

inhibit Thromboxane A2 (TXA2) synthesis which will result in impaired platelet aggregation

Question 7

why is aspirin special. explain MOA

Answer 7

increase the PGI2 TXA2 ratio as TXA2 levels are reduced more and for longer than PGI2. Platelets have no nucleus so cant synthesise COX

Question 8

how may NSAIDs act on renal and pulmonary systems respectively

Answer 8

compromise renal blood flow & bronchoconstrict

Question 9

what actions of paracetamol make it ‘special’?

Answer 9

especially used in children. analgesic and anti-pyretic but NOT anti-inflammatory

Question 10

what is a coxib?

Answer 10

selective cox-2 inhibitor