Drugs for HBV and HCV

Question 1

What drugs are used in the tx of chronic HBV and which is preferred?

Answer 1

Lamviduine, emtricitabine (HIV/HBV), tenofovir, entecavir, adefovir
Tenofovir or entacavir preferred

Question 2

Antiviral drug resistance tends to be ____ specific.

Answer 2

structure/sugar residue specific. Arise from mutations in HBV polymerase

Question 3

What HBV agents have L-nucleosides?

Answer 3

Lamivudine

Question 4

What HBV agents have acyclic phosphonates?

Answer 4

adefovir, tenofovir

Question 5

What HBV agents have d-cyclopentane?

Answer 5

entecavir

Question 6

If HBV becomes resistant to lamivudine, what will have some degree of reduced sensitivity?

Answer 6

entacavir

Question 7

If HBV becomes resistant to adefovir, what will have some degree of reduced sensitivity?

Answer 7

tenofovir, lamivudine,

Question 8

If HBV becomes resistant to entacavir, what will have some degree of reduced sensitivity?

Answer 8

lamivudine