Drugs For Final Flashcards
Doxorubocin
Anthracycline — target DNA Topoisomerase
Topoisomerase II Inhibitor
Daunorubocin
Anthracycline — target DNA Topoisomerase
Topoisomerase II Inhibitor
Irinotecan
Topoisomerase I inhibitor used for colorectal cancer
Valparoic Acid
HDAC inhibitor used as anti-cancer agent
Vorinostat
HDAC inhibitor used as anti-cancer agent
Rifampicin
Up-regulation of p450 causing rapid drug metabolization
RNA Synthesis inhibitor
Herceptin
HER2 receptor inhibitor via activation of antibody-dependent cell-mediated cytotoxicity
Gleevec
Prevents phosphorylation and inhibits BCR-ABL protein
Used in treatment of Chronic Myelogenous Leukemia (CML)
Taxol
Binds and stabilizes microtubules in order to prevent the rapid-growth of cells
Phalloidin
Binds and stabilizes filaments
Used in microscopy for actin filament visualization
Hepcidin
Blocks Ferroportin by causing internalization of transporter to be destroyed by proteolysis
High Iron = High Hepcidin expression
Streptomycin
Binds to the 30S subunit to disrupt initiation of translation
Shiga Toxin
Binds to the 60S subunit to disrupt elongation by preventing entry of aminoacyl-tRNA to ribosomal complex
Ricin
Binds to the 60S subunit to disrupt elongation by preventing entry of aminoacyl-tRNA to ribosomal complex
Clindamycin
Bind to the 50S subunit to disrupt translocation of the ribosome
Erythromycin
Bind to the 50S subunit to disrupt translocation of the ribosome
Commonly used to treat pertussis
Tetracyclines
Bind to the 30S subunit to disrupt elongation by preventing entry of aminoacyl-tRNA to ribosomal complex
Diphtheria Toxin
Inactivates EF2-GTP (eukaryotes) and inhibits elongation
Chloramphenicol
Inhibits peptidyl transferase in prokaryotes and mitochondria
Puromycin
An elongation inhibitor that causes premature chain termination in prokaryotes and eukaryotes by releasing the polypeptide prematurely and stopping the ribosome
