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MCM > Drugs For Final > Flashcards

Drugs For Final Flashcards

1
Q

Doxorubocin

A

Anthracycline — target DNA Topoisomerase

Topoisomerase II Inhibitor

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2
Q

Daunorubocin

A

Anthracycline — target DNA Topoisomerase

Topoisomerase II Inhibitor

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3
Q

Irinotecan

A

Topoisomerase I inhibitor used for colorectal cancer

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4
Q

Valparoic Acid

A

HDAC inhibitor used as anti-cancer agent

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5
Q

Vorinostat

A

HDAC inhibitor used as anti-cancer agent

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6
Q

Rifampicin

A

Up-regulation of p450 causing rapid drug metabolization

RNA Synthesis inhibitor

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7
Q

Herceptin

A

HER2 receptor inhibitor via activation of antibody-dependent cell-mediated cytotoxicity

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8
Q

Gleevec

A

Prevents phosphorylation and inhibits BCR-ABL protein

Used in treatment of Chronic Myelogenous Leukemia (CML)

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9
Q

Taxol

A

Binds and stabilizes microtubules in order to prevent the rapid-growth of cells

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10
Q

Phalloidin

A

Binds and stabilizes filaments

Used in microscopy for actin filament visualization

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11
Q

Hepcidin

A

Blocks Ferroportin by causing internalization of transporter to be destroyed by proteolysis
High Iron = High Hepcidin expression

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12
Q

Streptomycin

A

Binds to the 30S subunit to disrupt initiation of translation

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13
Q

Shiga Toxin

A

Binds to the 60S subunit to disrupt elongation by preventing entry of aminoacyl-tRNA to ribosomal complex

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14
Q

Ricin

A

Binds to the 60S subunit to disrupt elongation by preventing entry of aminoacyl-tRNA to ribosomal complex

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15
Q

Clindamycin

A

Bind to the 50S subunit to disrupt translocation of the ribosome

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16
Q

Erythromycin

A

Bind to the 50S subunit to disrupt translocation of the ribosome
Commonly used to treat pertussis

17
Q

Tetracyclines

A

Bind to the 30S subunit to disrupt elongation by preventing entry of aminoacyl-tRNA to ribosomal complex

18
Q

Diphtheria Toxin

A

Inactivates EF2-GTP (eukaryotes) and inhibits elongation

19
Q

Chloramphenicol

A

Inhibits peptidyl transferase in prokaryotes and mitochondria

20
Q

Puromycin

A

An elongation inhibitor that causes premature chain termination in prokaryotes and eukaryotes by releasing the polypeptide prematurely and stopping the ribosome

MCM (5 decks)

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