Drugs For Coagulating Disorder Flashcards

1
Q

What are the classification of drugs in coagulation disorder

A

Antithrombics

Prothrombics

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2
Q

What are the types of antithrombics

A

Anticoagulants

Antiplatelets

Fibrinolytics

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3
Q

What are the types of prothrombics

A

Vitamin K

Epsilon-Aminocaproic Acid

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4
Q

What is the physiology of clot formation

A

Stimuli of clot formation

Protein and cellular events in clot formation

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5
Q

What are the different types of stimuli clot formation

A

Endothelial injury

Blood stasis

Prescence of foreign substance

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6
Q

What are the diffract types of protein and cellular events in clot formation

A

Platelet migration and aggregation

Activation of coagulation cascade

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7
Q

In platelet migration and aggregation what are the 2 subtypes

A

Pro aggregants

Anti aggregants

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8
Q

Pro-aggregants should promote..?

A

Clot

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9
Q

What are the different types of drugs in pro aggregants

A

TXA2

5-HT

ADP

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10
Q

What are the different types of drugs in anti aggregants

A

PGI2

PGE2

cAMP

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11
Q

What are the receptors dor platelet migration and aggregation

A

GPIa

GPIb

GPIIb/IIIa

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12
Q

GPIa bind to platelets to

A

Collgen

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13
Q

GPIb binding of platelets to..

A

Von willebrand factor

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14
Q

GPIIb/IIIa for??

A

Interplatelet binding (through fibrinogen)

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15
Q

What is the product in platelet migration and aggregation

A

Platelet plug / primary hemostasis white thrombus

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16
Q

In activation of blood coagulation cascade what is the goal??

A

To activate

fibrinogen(I) –> fibrin (Ia)

17
Q

What are the clotting factors of activation of blood coagulation cascade

A

Zymogen

Fibrin

18
Q

What are the pathways in Coagulation cascade

A

Extrinsic

Intrinsic

19
Q

What is the product in blood coagulation cascade

A

Secondary hemostasis
red thrombus
Stable

20
Q

In intrinsic pathway the damaged in??

A

Epithelium

21
Q

Extrinsic pathway damage in??

A

Tisuue