Drugs for CHF Flashcards
1
Q
Strategies to CHF Management
A
- Treat underlying disease
- Reduce preload
- Reduce afterload
- Reduce over-stimulation
- Strength heart contraction directly
2
Q
Preload
A
- Filling pressure of the heart at the end of diastole
- Greater preload, greater volume of blood in heart
3
Q
Afterload
A
- Pressures the ventricles must generate to eject blood during systole
- Force heart contracts against
- Dependent upon the pressures in the pulmonary artery(RV)/aorta (LV)
4
Q
Contractility
A
- Strength and rate of heart contraction
- Inotropy - altering force/energy of muscular contractions
- Lusitropy - rate of myocardial relaxation
- Chronotropy - heart rate and rhythm
- Dromotropy - conduction speed in nodes and impulses in heart
5
Q
Angiotensin II Effects
A
- Fibroblast activation
- CMC hypertrophy
- Cardiac and valvular remodeling
- Fluid retention
6
Q
Aldosterone Effects
A
- Gene transcription that causes sodium/water retention
- Binds to receptors on fibroblasts toward increasing fibrosis
7
Q
BNP + Effects
A
- Natiuretic peptides produced by heart due to excessive cardiomyocyte stretching
- Promotes vasodilation and diuresis (negative regulation to RAAS)
