DRUGS FOR CDI (Neurogenic)

Question 0

DDAVP ADVERSE EFFECTS

Answer 0

abd cramping
Rhinitis 
Mild HTN
TRANSIENT HEADACHE
NASAL CONGESTION
NAUSEA
FACIAL FLUSHING LOCAL ERYTHEMA, BURNING PAIN, SWELLING AT INJECTION SITE
NSAIDS ENHANCE ANTIDIURETIC RESPONSE

Question 1

DESMOPRESSIN

Answer 1

INTRANASALLY 
Synthetic analog of ADH
ENABLES kidneys to concentrate u time and conserve body water 
NEUROGENIC DIABETES INSIPIDUS 
PO, IV, SC, 
IV-hypovolemia

Question 2

Vasopressin (Lypressin)

Answer 2

Possesses press or and ADH properties produced concentrated Irvine by urine by increasing tubular absorption of water
Used in neurogenic DI
Short duration
INTRANASALLY, SC, IM replaced by DDAVP

Question 3

ADH releasing Drugs

Answer 3

Diabinese -Mild forms, potential the action of vasopressin
Tegretol- carbamazepine -presse effects
Atromid-S - hypolipidemic agent that has an ANTIDIURETIC effect on patients with some residual hypothalamic vasopressin

Question 4

Diuretics

Answer 4

Chlorothiozide (Diuril)

Useful in mold forms potentials the action of vadopressin

Question 5

Prostaglandin inhibitors

Answer 5

Indocin (indomethacin)

Question 6

Sulfonylurea compounds are alternative theraphy to DESMOPRESSIN and can be used in combination with thiazides diuretics

Answer 6

CHLOROPROPAMIDE

• produce a physiological anti diuresis
• dosage must be individualized
• avaliable only in tab form

Question 7

Thiazides diuretics

Answer 7

Impair sodium chloride reabsorption in the distal tubes

HYDROCHLORITHIAZIDE (ESIDRIX, HRYDRODIURL, MICROZIDE)

Question 8

Amiloride (Potassium sparing diuretic)

Answer 8

Risk of hypokalemia is decreased in combination with HYDROCHLORITHIAZIDE
2 agents are synergistic with respect to antidiuresis

Question 9

NSAIDS

Answer 9

Agents act synergistically with thiazides to finish urine volume
Indomethacin (indocin) - non steroidal prostaglandin inhibitor with antipyretic properties