Drugs for cases 1-4 Flashcards
Sodium Valproate/ Depakote inhibits which enzyme?
GABA Transaminase
Sodium Valproate has been shown to block 2 types of channel. which channels are these?
Voltage gated Na+ and T-type calcium channels
Sodium Valproate is used, as well as a mood stabilizer, to treat what?
Seizure disorders such as Epilepsy
what is the mechanism of Sodium Valproate?
inhibition of GABA Transaminase, causing increased GABA concentrations at receptor sites, leading to increased GABAergic inhibition.
which drug causes folate deficiency?
Sodium Valproate
Common side effects of Sodium Valproate
- Nausea
- Dyspepsia
- Weight gain
- Hepatic or renal impairment
- Dizziness or drowsiness
Paracetamol is a selective inhibitor of which COX?
COX-2
What does the inhibition of COX-2 prevent?
Prostaglandin formation, inhibiting inflammation
Paracetamol’s analgesic effect is due to what?
We don’t know
Why are saleable doses of paracetamol restricted?
To prevent use in self harm
Common side effects of Paracetamol?
- Allergic reaction is possible
- Renal disease in chronic high dose use
- Hepatotoxicity at doses over 150mg/kg, becoming symptomatic and leading to liver failure 48hrs or later after dose.
Ibuprofen is a _____________________ inhibitor
Ibuprofen is a non-selective COX inhibitor
Mechanism of Ibuprofen
Inhibition of COX-2 prevents prostaglandin formation, thus inhibiting inflammation. COX-1 inhibition leads to the unwanted GI side effects.
side effects of ibuprofen
- Nausea & dyspepsia
- GI ulceration/bleeding
- Risk of hypertension in chronic use
which NSAID is generally found to have the least side effects
Ibuprofen is generally found to have the least side-effects of the NSAIDs, at least at OTC doses.
