Drugs for ATI

Question 1

Benzos

Answer 1

Adverse Effects: ­ CNS depressants, toxicity (drowsiness, respiratory depression), paradoxical response

Question 2

Atypical anxiolytic

Answer 2

Buspirone (BuSpar)
dependency is less likely- no sedation
AE: dizziness, nausea, agitation, hypertensive crisis

Question 3

SSRI

Answer 3

inhibits serotonin reuptake
AE: Sexual dysfunction, weight gain, GI bleeding, fatigue
Serotonin syndrome- mental confusion, fever, agitation, anxiety, hallucinations, hyperreflexia, diaphoresis, tremors

Question 4

Atypical antidepressants

Answer 4

inhibit dopamine

Aid to quit smoking, seasonal depression, lowers seizure threshold

Question 5

TCA

Answer 5

anti depressant
block reuptake of NE and S
AD: orthostatic hypotension, anticholinergic effects, sedation, decreased seizure threshold

Question 6

MAOI

Answer 6

increased NE, D and S
Avoid tyramine foods ( aged cheese, cured meat, sauerkraut, beer, wine, yeast, fish sauce, soy sauce)
AE: orthostatic hypotension, HTN crisis

Question 7

Alcohol abstinence/withdrawal

Answer 7

Benzos ­ chlordiazepoxide, diazepam, lorazepam
ii. Adjunct meds ­ carbamazepine, clonidine, propranolol
iii. disulfiram (Antabuse) ­ aversion therapy
iv. naltrexone (Vivitrol) ­ suppresses cravings and pleasure of alcohol intake (opioid
withdrawal)
v. acamprosate (Campral) ­ decrease abstinence effects

Question 8

Opioids abstinence/withdrawal

Answer 8

i. methadone (Dolophine) ­ replaces opioid
ii. clonidine (Catapres) ­ reduces withdrawal effects
iii. buprenorphine (Subutex) ­ decreased cravings

Question 9

Reversible Cholinesterase Inhibitors

Answer 9

used to treat myasthenia gravis, Alzheimer’s disease, and Parkinson’s disease
1. pralidoxime (2­PAM) ­ reserve effect of echothiophate
2. neostigmine (Prostigmin)
3. ambenonium (Mytelase)
4. pyridostigmine (Mestinon)
5. edrophonium (Tensilon)
Adverse effects ­ excessive muscarinic stimulation (increased GI motility),
cholinergic crisis