Drugs for Angina Pectoris 1

Question 1

both major right and left coronary arteries branch off of what

Answer 1

aorta

Question 2

coronary arteries surround

Answer 2

the heart

Question 3

coronary arteries provide what to the heart

Answer 3

nutrients and oxygen

Question 4

if heart doesn’t get oxygen and nutrients then

Answer 4

muscle can become necrotic and lead to MI

Question 5

angina pectoris indicator for

Answer 5

coronary artery disease

Question 6

angina pectoris

Answer 6

sudden pain beneath the sternum, often radiating to left shoulder and arm

Question 7

oxygen supply to the heart is insufficient to meet

Answer 7

oxygen demand

Question 8

older women and angina pectoris

Answer 8

will not have classic symptoms, usually very fatigue, some complain of jaw pain; so people can have atypical symptoms

Question 9

Chronic stable angina (exertional):

Answer 9

predictable and usually relieved with rest; pt can predict what will cause chest pain

Question 10

Chronic stable angina (exertional) causes

Answer 10

emotional excitement; large meals; cold exposure; coronary artery disease (CAD)

Question 11

Unstable Angina:

Answer 11

Unpredictable, occurs with rest or excretion; May or may not respond to therapy; usually having a MI

Question 12

KNOW HOW BLOOD FLOWS THROUGH THE HEART

Answer 12

know

Question 13

Variant or Prinzmetal’s Angina cause

Answer 13

coronary spasm

Question 14

treatment goals and strategy of angina pectoris

Answer 14

Prevention of myocardial infarction and death; Prevention of myocardial ischemia and anginal pain; Decrease Oxygen demand; Increase Oxygen supply

Question 15

myocardial infarction

Answer 15

death of tissue

Question 16

myocardial ischemia

Answer 16

lack of oxygen and when want to do intervention

Question 17

number one treatment for angina pectoris is

Answer 17

calcium channel blockers

Question 18

what drugs can be used for MI

Answer 18

beta blockers

Question 19

calcium does what

Answer 19

depolarizes and leads to contraction of smooth muscle

Question 20

drugs used for angina pectoris:

Answer 20

Three families of antianginal agents - Organic nitrates, Beta blockers, Calcium channel blockers; Also used is - Aspirin (salicylates)

Question 21

an example of anti platelet drug

Answer 21

aspirin (salicylates)

Question 22

sublingual tablets

Answer 22

under the tongue, have great hepatic 1st pass effect

Question 23

sustained- release oral capsules

Answer 23

for maintenance issues, to keep vessels open

Question 24

transdermal delivery systems

Answer 24

patches

Question 25

intravenous infusion

Answer 25

(tradil - nitroglycerine drip )

Question 26

paste

Answer 26

most common; tape chest on paper, do not get on your fingers because will vasodilate you

Question 27

Organic Nitrates - Preparations and routes of administration

Answer 27

Sublingual tablets; Sustained-release oral capsules; Transdermal delivery systems; Translingual spray; Transmucosal (buccal) tablets; Topical ointment; Intravenous infusion

Question 28

NTG acts directly on what

Answer 28

vascular smooth muscle to promote vasodilation

Question 29

when vasodilate blood pressure

Answer 29

decreases; so monitor bp and might have to give blood interact

Question 30

nitroglycerin

Answer 30

heart and vessel dilator

Question 31

nitroglycerin is a

Answer 31

A Vasodilator that: decreases workload of heart muscle, and Decreases “preload” – amount of volume returning to heart

Question 32

preload

Answer 32

work of the heart; volume coming back to the heart

Question 33

nitroglycerin also decreases

Answer 33

afterload

Question 34

afterload

Answer 34

resistance left ventricle meets as trying to push out of the body, so vessels dilate so it doesn't have to work as heard

Question 35

adverse effects of nitroglycerin

Answer 35

headache, orthostatic hypotension, reflex tachycardia

Question 36

reflex tachycardia

Answer 36

heart responds to vasodilation, sometimes by pumping harder

Question 37

Viagra, Levitra, or Cialis

Answer 37

pretty strong vasodilators; combined w/ NTG will cause big problems

Question 38

can't use what w/in 24 hours of receiving NTG

Answer 38

Viagra or Levitra - Will cause significant: Hypotension, headaches, muscle aches and pains, GERD

Question 39

can't us what w/in 36 hours of receiving NTG

Answer 39

Cialis - will cause significant Hypotension, headaches, muscle aches and pains, GERD

Question 40

Interactions with NTG

Answer 40

Hypotensive drugs; Phosphodiesterase type 5 inhibitors (sildenafil –Viagra); Beta blockers, verapamil, and diltiazem

Question 41

viagra will do what with NTG

Answer 41

will further lower BP

Question 42

verapamil and diltiazem

Answer 42

calcium channel blockers

Question 43

When and how to take NTG:

Answer 43

: One tablet sublingually every 5 minutes x 3; If pain persists, call 911

Question 44

how to store NTG

Answer 44

in dry cool place; tablets are heat, light, and moisture sensitive; not in bathroom cabinet moisture and heat not good for med

Question 45

Nitrate Free Interval-

Answer 45

remove nitrate paste at night to prevent “tolerance” effect

Question 46

Tablets should _____ under tongue

Answer 46

“sizzle”

Question 47

NTG dates of bottles

Answer 47

date bottle when first opened; only good for 1-3 months

Question 48

with NTG have "golden hour"

Answer 48

sooner than later to open up vessel

Question 49

if use NTG paste

Answer 49

if use paste 24 hr a day then a tolerance effect will happen and vessels will become intolerant if paste is used continuos