Drugs at the Synapse Flashcards
What are the divisions of the PNS?
the autonomic (ANS) and somatic nervous systems
What is the role of the ANS in the body?
It is concerned primarily with visceral functions such as cardiac output, blood flow distribution, and digestion, which are necessary for life
It is largely independent (autonomous) in that its activities are not under direct conscious control
NOTE: There is growing evidence that it also has immune function (through the vagus nerve) and can influence cancer progression
What is the role of the somatic nervous system in the body?
largely responsible for consciously controlled functions such as movement, respiration, and posture.
Does the nervous system operate through electrical or chemical synapses?
Chemical.
Chemical transmission takes place through the release of small amounts of transmitter substances from the nerve terminals into the synaptic cleft and subsequent fusion with a postsynaptic membrane
What are the major divisions of the ANS?
sympathetic (aka thoracolumbar) and the parasympathetic (aka craniosacral)
The sympathetic preganglionic fibers leave the CNS through the which spinal nerves?
thoracic and lumbar spinal nerves.
The parasympathetic preganglionic fibers leave the CNS through which nerves?
the cranial nerves (especially 3, 7, 9, and 10) and the third and fourth sacral spinal nerve roots.
What are the types of preganglionic fibers of the sympathetic nervous system and where do they terminate?
1) paravertebral chains that lie on either side of the spinal column. (shorter fibers)
2) prevertebral ganglia, which lie in front of the vertebrae, usually on the ventral surface of the aorta (longer fibers)
From the ganglia, postganglionic sympathetic fibers run to the tissues innervated
The majority of parasympathetic preganglionic fibers terminate on ganglion cells distributed diffusely or in networks in the walls of the innervated organs. Which ones terminate in parasympathetic ganglia located outside the organs innervated?
the ciliary, pterygopalatine, submandibular, otic, and several pelvic ganglia
What is the enteric nervous system (ENS)?
a large and highly organized collection of neurons located in the walls of the gastrointestinal (GI) system. It is sometimes considered a third division of the ANS and is involved in both motor and secretory activities of the gut.
What are the two plexuses that make up the ENS?
myenteric plexus (the plexus of Auerbach) and the submucous plexus (the plexus of Meissner).
Does the ENS receive ganglionic fibers from both the sympathetic and parasympathetic systems?
Yes. The neural networks of the ENS receive preganglionic fibers from the parasympathetic system and postganglionic sympathetic axons
They also receive sensory input from within the wall of the gut.
Do the ganglionic fibers from the parasympathetic and sympathetic systems that enter the ENS provide an excitatory, inhibitory, or modulatory role?
A modulatory role, as indicated by the observation that deprivation of input from both ANS divisions does not abolish GI activity
What is the role of the ENS?
Fibers from the neuronal cell bodies in the myenteric and submucous plexuses travel forward, backward, and in a circular direction to the smooth muscle of the gut to control motility (especially of the colon) and to secretory cells in the mucosa to sense and influence their actions
The ENS also provides the necessary synchronization of impulses that, for example, ensures forward, not backward, propulsion of gut contents and relaxation of sphincters when the gut wall contracts.
How does the ENS work in a semiautonomous manner?
it utilizes input from the motor outflow of the ANS for modulation of GI activity and sends sensory information back to the CNS
Are they effects of neurotransmitter release at an ANS synapse more localized or more spread than neuromuscular synapses? Are they quicker or closer?
Why?
More spread out and slower
Junctions between autonomic neuron terminals and effector cells (smooth muscle, cardiac muscle, glands) differ from classic synapses in that transmitter is often released from a chain of varicosities in the postganglionic nerve fiber in the region of the smooth muscle cells rather than from boutons (as in neuromuscular synapses and most neuron-neuron synapses), and autonomic junctional clefts are wider than somatic synaptic clefts.
Effects are thus slower in onset and discharge of a single motor fiber often activates or inhibits many effector cells.
Peripheral ANS fibers that release acetylcholine as a neurotransmitter are called?
cholinergic.
Which ganglionic fibers in the PNS are cholinergic in nature?
All preganglionic efferent autonomic fibers, the somatic (nonautonomic) motor fibers to skeletal muscle, most parasympathetic postganglionic, and a few sympathetic postganglionic fibers
Thus, almost all efferent fibers leaving the CNS are cholinergic
Most postganglionic sympathetic fibers release which neurotransmitter?
norepinephrine (except sweat glands- acetylcholine)
Fibers which release norepinephrine as a neurotransmitter are called?
noradrenergic
What neurotransmitters do adrenal medullary cell secrete?
norepinephrine and epinephrine
What are the five key features of neurotransmitter function that provide potential targets for pharmacologic therapy?
synthesis, storage, release, termination of action of the transmitter, and receptor effects
What are VAMPs?
vesicle-associated membrane proteins (VAMPs), which serve to align vesicles with release sites on the inner neuronal cell membrane and participate in triggering the release of transmitter
What are SNAPs?
synaptosomal nerve-associated proteins (SNAPs). These are involved with fusion of VAMPs on the inner membrane of the presynaptic nerve membrane to aid in release of the transmitter
VAMPs and SNAPs are aka?
fusion proteins
Acetylcholine is synthesized from choline and acetyl CoA through the actions of which enzyme? Where in the neuron?
choline acetyltransferase (ChAT); cytoplasm
Acetyl-CoA is synthesized in mitochondria, which are present in large numbers in the nerve ending
T or F. Choline is synthesized in the cytoplasm of the neuron?
F. It is synthesized in the extracellular matrix
How is choline imported into the cytoplasm of the neuron at the pre-synaptic neuron terminal?
by a sodium-dependent membrane choline transporter (CHT)
What do the group of drugs called hemicholiniums do?
they block choline transporter (CHT)