Drugs and what they do

Question 1

Denosumab

Answer 1

Monoclonal antibody that works like the endogenous osteoprotegerin in binding to RANK-L ligand so that it does not bind to RANK receptors

Question 2

Bisphosphatase

Answer 2

1. They easily accumulate in the bone because they have a high affinity for calcium
2. Alendronate – most prescribed
3. 2 phosphonate groups
4. They target osteoclasts and cause a variety of toxic effects on these cells, so that they can apoptosis

Question 3

Teriparatide

Answer 3

fully active PTH fragment made up of 1-34 amino acids