Drugs And Sexuality

Question 1

What increases libido?

Answer 1

Testosterone, dopamine, estrogen (F)

Question 2

What decreases libido?

Answer 2

Prolactin, serotonin, estrogen (M)

Question 3

How does dopamine affect libido?

Answer 3

Increases with agonists

Question 4

How does NE affect libido?

Answer 4

Increases when more in synapse (a2 blockers)

Question 5

Role of ACh in libido

Answer 5

Nicotinic agonists inc

Muscarinic antag decrease

Question 6

Role of serotonin in libido

Answer 6

more 5HT in synapse decreases libido (antag)

Question 7

Best tx for premature ejaculation

Answer 7

Local anesthetics

Question 8

Drugs that inc libido

Answer 8

Testosterone (M/F)
Dopamine agonists (LDOPA, bromocriptine)

Question 9

PGE-1 (alprostadil)

Answer 9

ED tx
MOA: vasodilation
AE: hypotension, mild penile pain, priapism

Question 10

PDE5 Inhibitor (Sildenafil)

Answer 10

ED tx
MOA: prevents cGMP breakdown
AE: HA, flushing, hypotension

Question 11

What should you not take Sildenafil with?

Answer 11

Nitrates - can cause decreased cardiac perfusion and MI

Question 12

Tx for vaginal atrophy and dryness

Answer 12

Topical estrogen

Question 13

FDA approved drugs for dysparenunia

Answer 13

Prasterone, ospemifene