Drugs and Sexuality Flashcards
Two main ways that drug affects sex
- altering libido
- altering performance
What 3 things INCREASE libido?
TED
– testosterone (male & female)
– Dopamine
– Estrogen in females?
What three things decrease libido?
SEP
– prolactin (male & female)
– estrogen (male)
– serotonin
What’s the role CNS neurotransmitters in libido?
DAN increases
- dopamine
- NE
- ACh
What’s the role CNS neurotransmitters in libido?
SALLY decreases
- serotonin
What are the typical effects of drugs on sex?
DECREASE libido by
Hormonal:
– increasing prolactin secretion
– anti‐androgenic
CNS effects:
– block DAN, increase Sally
What would increase sexual response?
androgen receptor agonist (testosterone)
How could you interfere with orgasm?
alpha-1 blockade
antihypertensive drugs frequently cause sexual problems
α1 blockers: high incidence of ejaculatory failure (but not
of erection)
Which anti-HTN have few sexual side effects?
CCB, ACE, ARBs, DRIs
Psychiatric drugs:
A common source of sexual problems
But: the disease state itself often affects sexuality,
complicating analysis of drug effects
Antipsychotic problems
Decreased libido due to
– DA receptor blockade
– CNS anticholinergic effects
– CNS sedative effects
• Problems w/ erection due to peripheral ACh effects
• Problems w/ orgasm due to peripheral α1 blocka
What is the only antipsychotic drug that increases libido??
Levodopa: enhanced libido (increased DA)
What effects does acute alcohol ingestion have?
disinhibiting, less intense orgasm
What effect does chronic alcohol ingestion have?
Neuropathy
decreased testosterone