Drugs affecting hemostasis Flashcards
What are the types of drugs that affect hemostasis?
Anticoagulants Direct Thrombin Inhibitors Heparin Antagonists Hemostatics Thrombolytic Agents Platelet Inhibitors
Coagulation, along with fibrinolysis and wound healing are largely responsible for maintaining the circulation as a closed hemodynamic system in a normal basal state equilibrium, referred to as
Hemostasis
What is Virchow’s triad?
Hypercoagulable state
Vascular wall injury
Circulatory stasis
Damage outside blood vessels triggers the release of thromboplastin (Factor III, tissue factor) from damaged cells.
Extrinsic pathway
What activates factor VII?
Thromboplastin
Both the extrinsic and intrinsic pathways can activate which factor?
X
Thromboplastin activates factor ______, ______ when complexed on the surface of the platelet with calcium _________ and thromboplastin _____ activates factor__.
VII; VIIa; IV; IIIa; X
The extrinsic pathway is inhibited by . . .
Coumadin, PT/INR
Describe the Intrinsic pathway: Trauma to the blood activates factor ____ which activates factor ____ and activates factor _____, which when on the platelet surface activates factor _____ and calcium which activates factor ___.
XII; XI; IX; VIII:C; X
The intrinsic pathway is inhibited by. . .
Heparin; Aptt
Which factor is Calcium?
IV
Describe the Common Pathway: Factor Xa on the platelet surface with factor ___ and calcium converts ________ to Thrombin
V; Prothrombin (IIa)
Which factor converts fibrinogen to fibrin?
Prothrombin (IIa)
What occurs when factor XIII is present in the conversion of fibrinogen to fibrin?
cross-linking
What system and meds does the Bleeding time test?
Platelets and Capillaries; ASA, Plavix, Ticlid, poss. NSAIDs
What system and meds does the PT test?
Extrinsic, common pathways; Warfarin
What system and meds does the aPTT test?
Intrinsic, Common pathways; heparin
What system and meds does the TT (thrombin time) test?
Fibrinogen to Fibrin; Heparin
This med is an anionic, sulfated, glycosoaminoglycan found in the secretory granules of mast cells. . .
Heparin