Drugs affecting childbearing women and newborns Flashcards
(136 cards)
When does the teratogenic period begin:
two weeks after conception
Substances that causes developmental abnormalities are defined as:
teratogens
How is iron to be used during pregnancy:
- Iron is vital to hemoglobin regeneration. only twice the normal requirement (18-30 mg) between the second and third semester
- The goal is to prevent maternal iron deficiency anemia, not to supply the fetus
- Supplementation w/iron is not necessary until second trimester
- The time of greatest demand is in third trimester of 22.4 mg/day d/t women having a decreased hematocrit
What are the common side/adverse effects of iron:
N/V/D, constipation, black-tarry stools, GI irritation, epigastric pain (mostly GI related)
What are the nursing implications/considerations when giving iron:
- 1: liquid forms can discolor teeth=dilute and give w/a straw
- Iron supplements are best absorbed on an empty stomach or w/water & juice 1 h before meals
- If GI irritation occurs, give with food
- iron should be administered 2 h before or 4 h after antiacids/levodopa/levothyroxine/methyldopa/penicillamine/quinolones/tetracyclines d/t iron inhibiting absorption of medications
- Foods rich in iron: liver, red meat, wheat germ, spinach, prunes
- Do not administer iron w/milk, cereals, tea, coffee, or eggs
How is folic acid used during pregnancy:
- Part of preconception planning to improve outcomes of pregnancy d/t spontaneous abortion/birth defects/neural tube defects (leading to spina bifida/skull/brain malformations)/premature birth/premature separation of placenta
- Three approaches are recommended for child-bearing aged women (supplementation at 400-600 mcg, dietary fortification, food choices) d/t neural tube closure within the first 4 wks of pregnancy
- folate-rich foods are breads/flour/cornmeal/rice/pasta/cereals
What are the side/adverse effects of folic acid:
Not common, but may occur as: allergic bronchospasm/rash/pruritus/erythema/general malaise
How are prenatal vitamins used during pregnancy:
- prenatal vitamins generally provide A/D/C/B complex/B12/iron/Ca
- Role of prenatal vitamins in preventing congenital defects is UKN
- Megadoses of vitamins/minerals during pregnancy will not improve health and may cause harm to the fetus and the mother
- Most common reason for non-compliance is d/t iron causing N/V
- Be culturally aware. Eg: Pts from Mexico believe that taking vitamins is considered a “hot” food that should not be ingested during pregnancy
Severe N/V that may require hospitalization to replace hydration and nutrition is defined as and what is given for Tx:
- hyperemesis gravidarum
- Reglan or Zofran may be given
- If a pt is experiencing 5% in weightloss when they should be ganing weight must be treated at a hospital immediately as it is life-threatening to the fetus (labs may see spilled keytones, low SG from urinalysis)
What are some considerations when choosing a contraceptive method:
- Safety: not safe for everyone
- Protection from STI’s: when using a condom, not pills/injections…
- Effectiveness: if taken as should
- Convenience: depends on pt
- Acceptability: depends on knowledge/choice
- Education Needed
- Side Effects
What are the types of contraceptives:
Hormonal & pharmacological
- OCP
- injections/implants
- IUD: intrauterine Devices
- Cervical rings
- transdermal patch
- Emergency contraception
What effect of the estrogen and the progestrin have to prevent pregnancy when taking a combination OCP:
Estrogen:
- prohibits ovulation by preventing the formation of the dominant follicle
- stabalizes uterine endometrium to stop irregular bleeding
Progestrin
- Suppresses LH surge
- Decreases circulatory S/S
- Changes the landscape of the endometrium to make it less favorable for sperm implantation
- Causes the viscosity of the cervical mucous to be thick and hostile towards sperm
What are the advantages of taking a COC pill:
- Shorter periods
- Decreased bleeding/uterine changes/PID (pelvic inflammatory diseas
- Decreased risks of ovarian/endometrial CA/osteoporosis
- Helps prevent ovarian cysts
- Decrease etopic pregnancy
Why is the COC (Combintion) the most common birth control pill to take:
- High degree of effectiveness
- less side effects d/t the combination of estrogen and progestrin than the progestrin only pill
- Supresses pituitary release of LH and FSH
- Come in varying dosages: monophasic (A fixed ratio of estrogen to progestrin), biphasic (Estrogen is fixed, but progestrin varies), triphasic (both estrogen and progestrin varies)
What does the progestrin “mini-pill” do:
- Interference of the endometrial lining causing implatation to be difficult
- Alters cervical mucosa making it thick nd viscous blocking sperm penetration
- Decreases perstalsis of the fallopian tubes slowing the transport of sperm
- Interferes w/LH surge inhibiting ovulation (only 50% of cycles)
- slightly less effective than the combination pill
- Should be taken 4-6 h before intercourse d/t the time it takes to alter the cervical mucosa to prevent sperm penetration
- If the mini pill is taken more than 3 h late, than a backup method should be used for 48 h
Why is better to take a monophasic pill rather than a bi/triphasic pill:
- Monophasic pills provide a fixed amount of estrogen throughout the menstral cycle which increases the effectiveness in preventing pregnancies.
- The bi/triphasic pills provide varying doses of either estrogen or progestrin which cause less side effects, but won’t be as efective in preventing pregnancies d/t the varying amount of estrogen
What are some drug interactions when taking OCPs:
The interaction of the following drugs decreases the effectiveness of the OCP. Have pts use a backup method for the duration of Tx and 7 days after
- anticonvulsants
- AntiTB meds: rifampin
- ABX
- barbiturates
- Hypnotics/sedatives
Drugs that may increase CHC activity:
- acetaminophen
- ascorbic acid
- fluconazole
Other Drug Interactions (use alternate means of contraception):
- anticoagulants: CHC increase clotting and decreases effectiveness of anticoagulants
- Anticonvulsants: CHC may increase SZ risks
What are the contraindications to OCP (the absolute and the caution when using)
**Absolute Contrandications: **
Hx of
- BA/estrogen-dependent CA
- Thromboembolitic disorders/vascular disease
- Cerebrovascular/CVD
- Liver tumors
Other Absolute Contradications
- Pregnancy (known or suspected)
- Diabetic complications or diabetes >20 y
- UNK vaginal bleeding
- HTN 160/100 and above
- Heavy smoker or >35 ys
- Use of drugs that affect liver enzymes (anticoagulants, rifampin)
Caution
- >35 y &
- >40 yo
- Non-insulin dependent DM
- Controlled or mild HTN
What are the side effects when taking OCP:
Excess estrogen effects:
- PMS like-S/S (N/V, edema, fluid retention, bloating, breast enlargement/tenderness), chloasma (hyper-pigmentation=brn spots near the eyes)
- Not so common ones: leg cramps, vascular HA, Visual changes, HTN
Excess Progestrin Effects:
- Increased appetite/weight gain, oily skin/scalp/acne, depression, vaginitis d/t yeast, hirsutism, decreased breast size, amenorrhea (absence of period)/spotting
What can pts take when they are contraindicated for combination birth control:
These pts can take a progestrin mini pill, no estrogen pill
What are the advantages in taking an alternative method to OCP:
- avoid GI absorption and therefore bypassing the “first-pass effect” of the liver
- Avoid OCP S/S like: N/V, blood clots, non-compliance
What are the types of contraceptive hormonal injections and what are the frequencies, route, and side effects:
Depo-Provera (medroxy_progesterone (only_):
- A progestrin injection given once every 3 mo IM into either the deltoid or the ventrogluteal muscle, or subcut (anterior thigh or abd, should NOT be massaged after injection as it can decrease effectiveness); sideeffects include weight gain, spotting/irregular bleeding, depression (period may cease 1 y after), bone density loss (have pt take V-D and Ca and do weight bearing exercises)
Lunelle (combination)
- No info in books, monthly IM, assume combination side effects
What implant contraceptive is given and what is its frequency, route, and side effects:
Implanon
- Single rod low-dose progesterin implant inserted in the subdermis of the upper inner arm which stays in place for 3 yrs
- side effect: 20% of women may have amenorrhea for the duration of the implant
What is the frequency, route, and side effects of NuvaRing:
NuvaRing
- A soft, plastic ring inserted into the vagina for 3 wks and take out on the 4th week; administers both estrogen and progestin
- Side effects include expulsion, vaginal discharge, discomfor, can’t be worn by pts over 198 lbs, must be re-fitted if weight fluctuatest; if taken out for more than 3 hrs, backup is required until 7 days after new insertion of ring